The role of vitamin D level and related single nucleotide polymorphisms in Crohn's disease

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dc.contributor.authorCarvalho A.Y.O.M.
dc.contributor.authorBishop K.S.
dc.contributor.authorHan D.Y.
dc.contributor.authorEllett S.
dc.contributor.authorJesuthasan A.
dc.contributor.authorLam W.J.
dc.contributor.authorFerguson L.R.
dc.date.accessioned2024-03-13T01:06:07Z
dc.date.available2024-03-13T01:06:07Z
dc.date.issued2013
dc.description.abstractNew Zealand has one of the highest rates of Crohn's Disease (CD) in the world, and there is much speculation as to why this might be. A high risk of CD has been associated with deficient or insufficient levels of Vitamin D (Vit D), lifestyle as well as various genetic polymorphisms. In this study we sought to analyse the relevance of serum Vit D levels, lifestyle and genotype to CD status. Serum samples were analysed for 25-OH-Vitamin D levels. DNA was isolated from blood and cheek-swabs, and Sequenom and ImmunoChip techniques were used for genotyping. Serum Vit D levels were significantly lower in CD patients (mean = 49.5 mg/L) than those found in controls (mean = 58.9 mg/L, p = 4.74 × 10-6). A total of seven single nucleotide polymorphisms were examined for effects on serum Vit D levels, with adjustment for confounding variables. Two variants: rs731236[A] (VDR) and rs732594[A] (SCUBE3) showed a significant association with serum Vit D levels in CD patients. Four variants: rs7975232[A] (VDR), rs732594[A] (SCUBE3), and rs2980[T] and rs2981[A] (PHF-11) showed a significant association with serum Vit D levels in the control group. This study demonstrates a significant interaction between Vit D levels and CD susceptibility, as well as a significant association between Vit D levels and genotype. © 2013 by the authors; licensee MDPI, Basel, Switzerland.
dc.description.firstpage3898
dc.description.issuenumber10
dc.description.lastpage3909
dc.description.volume5
dc.identifier.doi10.3390/nu5103898
dc.identifier.issn2072-6643
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/36697
dc.relation.ispartofNutrients
dc.rightsAcesso Aberto
dc.subject.otherlanguageCrohn's disease
dc.subject.otherlanguageLifestyle
dc.subject.otherlanguagePHF-11
dc.subject.otherlanguagePPP6R3
dc.subject.otherlanguageSCUBE3
dc.subject.otherlanguageSNPs
dc.subject.otherlanguageVDR
dc.subject.otherlanguageVitamin D levels
dc.titleThe role of vitamin D level and related single nucleotide polymorphisms in Crohn's disease
dc.typeArtigo
local.scopus.citations17
local.scopus.eid2-s2.0-84884679854
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84884679854&origin=inward
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