Neurostimulation for cognitive rehabilitation in stroke (NeuroCog): Study protocol for a randomized controlled trial

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dc.contributor.authorAndrade S.M.
dc.contributor.authorFernandez-Calvo B.
dc.contributor.authorBoggio P.S.
dc.contributor.authorde Oliveira E.A.
dc.contributor.authorGomes L.F.
dc.contributor.authorPinheiro Junior J.E.G.
dc.contributor.authorRodrigues R.M.
dc.contributor.authorde Almeida N.L.
dc.contributor.authorMoreira G.M.S.
dc.contributor.authorAlves N.T.
dc.date.accessioned2024-03-13T00:56:19Z
dc.date.available2024-03-13T00:56:19Z
dc.date.issued2015
dc.description.abstract© 2015 Andrade et al.Background: Stroke patients may present severe cognitive impairments, primarily related to executive functions. Transcranial direct current stimulation has shown promising results, with neuromodulatory and neuroplastic effects. This study is a double-blind, sham-controlled clinical trial aiming to compare the long-term effects of stimulation in two different cognitive regions after a stroke. Methods/Design: Sixty patients who suffer from chronic strokes will be randomized into one of four groups: dorsolateral prefrontal cortex, cingulo-opercular network, motor primary cortex and sham stimulation. Each group will receive transcranial direct current stimulation at an intensity of 2mA for 20minutes daily for 10 consecutive days. Patients will be assessed with a Dysexecutive Questionnaire, Semantic Fluency Test, categorical verbal fluency and Go-no go tests, Wechsler Adult Intelligence Scale, Rey Auditory-Verbal Learning Test, Letter Comparison and Pattern Comparison Tasks at baseline and after their tenth stimulation session. Those who achieve clinical improvement with neurostimulation will be invited to receive treatment for 12months as part of a follow-up study. Discussion: Long-term stimulation could be analyzed in regard to possible adaptive changes on plasticity after structural brain damage and if these changes are different in terms of clinical improvement when applied to two important cognitive centers. Trials registration: Clinicaltrials.gov, NCT02315807. 9 December 2014.
dc.description.issuenumber1
dc.description.volume16
dc.identifier.doi10.1186/s13063-015-0945-1
dc.identifier.issn1745-6215
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/36148
dc.relation.ispartofTrials
dc.rightsAcesso Aberto
dc.subject.otherlanguageClinical trial
dc.subject.otherlanguageCognitive rehabilitation
dc.subject.otherlanguageTranscranial direct current stimulation
dc.titleNeurostimulation for cognitive rehabilitation in stroke (NeuroCog): Study protocol for a randomized controlled trial
dc.typeArtigo
local.scopus.citations3
local.scopus.eid2-s2.0-84942609927
local.scopus.subjectAdolescent
local.scopus.subjectAdult
local.scopus.subjectBrazil
local.scopus.subjectCerebral Cortex
local.scopus.subjectClinical Protocols
local.scopus.subjectCognition
local.scopus.subjectCognition Disorders
local.scopus.subjectDouble-Blind Method
local.scopus.subjectFemale
local.scopus.subjectHumans
local.scopus.subjectMale
local.scopus.subjectMiddle Aged
local.scopus.subjectNeuropsychological Tests
local.scopus.subjectRecovery of Function
local.scopus.subjectResearch Design
local.scopus.subjectStroke
local.scopus.subjectStroke Rehabilitation
local.scopus.subjectSurveys and Questionnaires
local.scopus.subjectTime Factors
local.scopus.subjectTranscranial Direct Current Stimulation
local.scopus.subjectTreatment Outcome
local.scopus.subjectYoung Adult
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84942609927&origin=inward
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