Indirect voltammetric determination of thiomersal in influenza vaccine using photo-degradation and graphene quantum dots modified glassy carbon electrode

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dc.contributor.authorPedrozo-Penafiel M.J.
dc.contributor.authorMiranda-Andrades J.R.
dc.contributor.authorGutierrez-Beleno L.M.
dc.contributor.authorLarrude D.G.
dc.contributor.authorAucelio R.Q.
dc.date.accessioned2024-03-12T23:47:18Z
dc.date.available2024-03-12T23:47:18Z
dc.date.issued2020
dc.description.abstract© 2020 Elsevier B.V.Thiomersal is an organomercury derivative that degrades producing thiosalicylic acid, dithiobenzoic acid and ethylmercury. It is widely used in topical pharmaceutical preparations and as preservative in vaccines and cosmetics. In this work, an electro-analytical method for thiomersal was developed using graphene quantum dots (GQDs) as a surface modifier of a glassy carbon electrode. The method rely on using square-wave voltammetry and exploring the synergistic effect between GQDs, visible radiation and the applied potential in producing very intense Hg oxidation peak during the anodic scan. A linear voltammetric response was obtained for the analyte in the concentration range from 3.0 μmol L−1 (1.2 μg mL−1) to 32 μmol L−1 (12 μg mL−1), with a detection limit of 0.9 μmol L−1 (0.34 μg mL−1). The proposed method was successfully applied for thiomersal determination in influenza vaccine.
dc.description.volume215
dc.identifier.doi10.1016/j.talanta.2020.120938
dc.identifier.issn0039-9140
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/34943
dc.relation.ispartofTalanta
dc.rightsAcesso Aberto
dc.subject.otherlanguageGraphene quantum dots
dc.subject.otherlanguageInfluenza vaccine
dc.subject.otherlanguageMercury
dc.subject.otherlanguageModified glassy carbon
dc.subject.otherlanguageThiomersal
dc.subject.otherlanguageVoltammetry
dc.titleIndirect voltammetric determination of thiomersal in influenza vaccine using photo-degradation and graphene quantum dots modified glassy carbon electrode
dc.typeArtigo
local.scopus.citations9
local.scopus.eid2-s2.0-85081986252
local.scopus.subjectGlassy carbon electrodes
local.scopus.subjectInfluenza vaccines
local.scopus.subjectModified glassy carbon electrode
local.scopus.subjectPharmaceutical preparations
local.scopus.subjectSquare wave voltammetry
local.scopus.subjectThiomersal
local.scopus.subjectVoltammetric determination
local.scopus.subjectVoltammetric response
local.scopus.subjectCarbon
local.scopus.subjectElectrochemical Techniques
local.scopus.subjectElectrodes
local.scopus.subjectInfluenza Vaccines
local.scopus.subjectParticle Size
local.scopus.subjectPhotochemical Processes
local.scopus.subjectQuantum Dots
local.scopus.subjectSurface Properties
local.scopus.subjectThimerosal
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85081986252&origin=inward
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