Voltammetric determination of creatinine using a gold electrode modified with Nafion mixed with graphene quantum dots-copper
Tipo
Artigo
Data de publicação
2020
Periódico
Journal of Electroanalytical Chemistry
Citações (Scopus)
18
Autores
Pedrozo-Penafiel M.J.
Lopes T.
Gutierrez-Beleno L.M.
Da Costa M.E.H.M.
Larrude D.G.
Aucelio R.Q.
Lopes T.
Gutierrez-Beleno L.M.
Da Costa M.E.H.M.
Larrude D.G.
Aucelio R.Q.
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Resumo
© 2020 Elsevier B.V.Creatinine levels in blood and urine can be used as an important biomarker for the diagnosis of renal, thyroid, and muscle malfunctions. In this work, a square-wave voltammetric method for creatinine was developed using a gold electrode modified with a film composed by Nafion mixed with a graphene quantum dots dispersion prepared in the presence of Cu2+. Such Au/Nafion-GQDs-Cu electrode relies on the interactions of creatinine with Cu2+ released from the oxidation of Cu thus decreasing the characteristic Cu/Cu2+ anodic peak at +350 mV. A linear response was obtained for the analyte in the concentration range from 1.0 × 10−6 mol L−1 (0.11 mg L−1) to 4.5 × 10−4 mol L−1 (50.9 mg L−1). The proposed sensor was simple to prepare and the method was successfully applied for creatinine determination in urine samples.
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Assuntos Scopus
Anodic peaks , Concentration ranges , Gold electrodes , Linear response , Square waves , Urine sample , Voltammetric determination , Voltammetric methods