Liver regeneration with l-glutamine supplemented diet: Experimental study in rats Avaliação da regeneração hepática com dieta suplementada com l-glutamina: Estudo experimental em ratos

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dc.contributor.authorMagalhaes C.R.
dc.contributor.authorMalafaia O.
dc.contributor.authorTorres O.J.M.
dc.contributor.authorMoreira L.B.
dc.contributor.authorTefil S.C.S.G.
dc.contributor.authorPinherio M.R.
dc.contributor.authorHarada B.A.
dc.date.accessioned2024-03-13T01:02:23Z
dc.date.available2024-03-13T01:02:23Z
dc.date.issued2014
dc.description.abstractObjective: To assess liver regeneration in rats after 60% hepatectomy with and without supplementation of L-glutamine through liver weight changes, laboratory parameters and histological study. Methods: 36 male rats were divided into two groups: glutamine group and control group. Each group was subdivided into three subgroups, with death in 24h, 72h and seven days. The glutamine group received water and standard diet supplemented with L-glutamine, and the control recieved 0.9% saline. In all subgroups analysis of liver regeneration was made by the Kwon formula, study of liver function (AST, ALT, GGT, total bilirubin, indirect and indirect bilirubin and albumin) and analysis of cell mitosis by hematoxylin-eosin. Results: In both groups there was liver regeneration by weight gain. Gamma-GT increased significantly in the control group (p < 0.05); albumin increased in the glutamine group. The other indicators of liver function showed no significant differences. Histological analysis at 72h showed a higher number of mitoses in the glutamine group, with no differences in other subgroups. Conclusion: Diet supplementation with L glutamine is beneficial for liver regeneration.
dc.description.firstpage117
dc.description.issuenumber2
dc.description.lastpage121
dc.description.volume41
dc.identifier.doi10.1590/S0100-69912014000200008
dc.identifier.issn1809-4546
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/36488
dc.relation.ispartofRevista do Colegio Brasileiro de Cirurgioes
dc.rightsAcesso Aberto
dc.subject.otherlanguageDiet
dc.subject.otherlanguageEvaluation
dc.subject.otherlanguageGlutamine
dc.subject.otherlanguageHepatectomy
dc.subject.otherlanguageLiver regeneration
dc.titleLiver regeneration with l-glutamine supplemented diet: Experimental study in rats Avaliação da regeneração hepática com dieta suplementada com l-glutamina: Estudo experimental em ratos
dc.typeArtigo
local.scopus.citations12
local.scopus.eid2-s2.0-84902497868
local.scopus.subjectAnimals
local.scopus.subjectDietary Supplements
local.scopus.subjectGlutamine
local.scopus.subjectLiver Regeneration
local.scopus.subjectMale
local.scopus.subjectRats
local.scopus.subjectRats, Wistar
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84902497868&origin=inward
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