A four-year follow-up controlled study of stress response and symptom persistence in Brazilian children and adolescents with attention deficit disorder and hyperactivity (ADHD)

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dc.contributor.authorPalma S.M.M.
dc.contributor.authorNatale A.C.M.P.
dc.contributor.authorMaria Calil H.
dc.date.accessioned2024-03-13T00:55:45Z
dc.date.available2024-03-13T00:55:45Z
dc.date.issued2015
dc.description.abstract© 2015 Elsevier Ireland Ltd.This study evaluated children and adolescents with Attention Deficit Disorder andHyperactivity Disorder (ADHD), reassessing them at a four-year follow-up. Their cortisol response to a stress stimulus was measured twice. ADHD symptom persistence, development of comorbidities, and psychostimulant usage were also reassessed. The initial sample consisted of 38 ADHD patients and 38 healthy controls, age ranging 6-14. At the follow-up, there were 37 ADHD patients and 22 healthy controls, age ranging 10-18. ADHD was classified as persistent if the patients fulfilled all DSM IV criteria for syndromic or subthreshold or had functional impairment. Salivary cortisol samples were collected prior to the application of a cognitive stressor (Continuous Performance Test - CPT), and at three time intervals afterwards at baseline and at the follow-up. Their reassessment showed that 75% had persistent symptoms, psychiatric comorbidities (oppositional defiant and behavioral disorders), functional and academic impairement. Only seven patients were on medication. The ADHD group's cortisol levels were lower than those measured four years earlier, but cortisol concentrations were similar for both ADHD and control groups at the four-year follow-up. The cortisol results suggest that HPA axis reactivity could be a marker differentiating ADHD from ADHD with comorbidities.
dc.description.firstpage227
dc.description.issuenumber2
dc.description.lastpage232
dc.description.volume230
dc.identifier.doi10.1016/j.psychres.2015.08.044
dc.identifier.issn1872-7123
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/36117
dc.relation.ispartofPsychiatry Research
dc.rightsAcesso Restrito
dc.subject.otherlanguageComorbidity
dc.subject.otherlanguageContinuous performance test
dc.subject.otherlanguageCortisol
dc.subject.otherlanguageHypothalamic pituitary axis
dc.subject.otherlanguageImpulsivity
dc.subject.otherlanguageInattention
dc.subject.otherlanguagePersistence
dc.titleA four-year follow-up controlled study of stress response and symptom persistence in Brazilian children and adolescents with attention deficit disorder and hyperactivity (ADHD)
dc.typeArtigo
local.scopus.citations3
local.scopus.eid2-s2.0-84941236542
local.scopus.subjectAdolescent
local.scopus.subjectAttention Deficit Disorder with Hyperactivity
local.scopus.subjectBrazil
local.scopus.subjectChild
local.scopus.subjectDiagnostic and Statistical Manual of Mental Disorders
local.scopus.subjectFemale
local.scopus.subjectFollow-Up Studies
local.scopus.subjectHumans
local.scopus.subjectHydrocortisone
local.scopus.subjectHypothalamo-Hypophyseal System
local.scopus.subjectLongitudinal Studies
local.scopus.subjectMale
local.scopus.subjectPituitary-Adrenal System
local.scopus.subjectProspective Studies
local.scopus.subjectSaliva
local.scopus.subjectStress, Psychological
local.scopus.subjectTime Factors
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84941236542&origin=inward
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