High 15-F2t-isoprostane levels in patients with a previous history of nonmelanoma skin cancer: The effects of supplementary antioxidant therapy

De Jesus E Silva De Almendra Freitas B.; Lloret G.R.; Visacri M.B.; Tuan B.T.; Amaral L.S.; Baldini D.; De Sousa V.M.; De Castro L.L.; Aguiar J.R.S.; De Carvalho Pincinato E.; Mazzola P.G.; Moriel P.

High 15-F2t-isoprostane levels in patients with a previous history of nonmelanoma skin cancer: The effects of supplementary antioxidant therapy

Tipo

Artigo

Data de publicação

2015

Periódico

BioMed Research International

Citações (Scopus)

8

Autores

De Jesus E Silva De Almendra Freitas B.
Lloret G.R.
Visacri M.B.
Tuan B.T.
Amaral L.S.
Baldini D.
De Sousa V.M.
De Castro L.L.
Aguiar J.R.S.
De Carvalho Pincinato E.
Mazzola P.G.
Moriel P.

Resumo

Copyright © 2015 Betânia de Jesus e Silva de Almendra Freitas et al.Background. Phase I of this study was aimed at comparing the profiles of oxidative stress biomarkers in patients with history of nonmelanoma skin cancer (NMSC), previously treated with surgery, to the healthy subjects. Phase II aimed to evaluate the effects of supplementary antioxidant therapy on the levels of biomarkers in the case group. Materials and Methods. In Phase I, oxidative stress biomarkers were measured in blood samples obtained from 24 healthy subjects and 60 patients with history of NMSC previously treated with surgery. In Phase II, the 60 patients with history of NMSC were randomized into two subgroups, one receiving placebo (n = 34) and the other (n = 26) receiving vitamin C, vitamin E, and zinc supplementation for 8 weeks, followed by reevaluation of biomarkers. Results. In Phase I, patients with history of NMSC showed increased plasma concentrations of all biomarkers, but only 15-F2t-isoprostane was significantly higher than in the healthy subjects. Risk of NMSC increased by 4% for each additional 1 pg/mL increase in 15-F2t-isoprostane. In Phase II, supplementation did not significantly reduce levels of oxidative stress biomarkers. Conclusion. Patients with history of NMSC had significantly high 15-F2t-isoprostane plasma levels; supplementation did not result in significant reduction of oxidative stress biomarkers. This trial was registered with ClinicalTrials.gov (ID NCT02248584).

Assuntos Scopus

Adult , Aged , Antioxidants , Ascorbic Acid , Biomarkers, Tumor , Dietary Supplements , Female , Humans , Isoprostanes , Male , Middle Aged , Oxidative Stress , Skin Neoplasms , Vitamin E , Zinc