Evaluation of Prolonged Exposure to Varenicline in Adult Rats: Haematological, Biochemical and Anatomopathological Studies

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dc.contributor.authorZaccarelli-Magalhaes J.
dc.contributor.authorMoreira N.
dc.contributor.authorSandini T.M.
dc.contributor.authorde Abreu G.R.
dc.contributor.authorSanchez-Sarmiento A.M.
dc.contributor.authorRicci E.L.
dc.contributor.authorFukushima A.R.
dc.contributor.authorde Souza Spinosa H.
dc.date.accessioned2024-03-12T23:58:23Z
dc.date.available2024-03-12T23:58:23Z
dc.date.issued2018
dc.description.abstract© 2017 Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society)Varenicline is a synthetic chemical substance produced from the alkaloid cytisine, used for smoking treatment, which acts as a partial agonist for α4β2 and α3β4 nicotinic cholinergic receptors and as a total agonist for α7 receptor. While there are studies regarding varenicline's non-smoking-related effects, as in treatment for drug dependence, there are no studies in the literature evaluating the long-term toxicity of varenicline through a physiological approach. Thus, the aim of this study was to evaluate possible toxicity through haematological, biochemical and anatomopathological parameters of prolonged exposure (30 days) to varenicline in rats. Three doses of varenicline were used: 0.03 (therapeutic dose for human beings), 0.1 and 0.3 mg/kg orally (gavage). Body-weight, water and food intake were measured weekly during treatment. On the 30th treatment day, blood and various organs were collected for haematological, biochemical and anatomopathological evaluations. The results show a decrease in some biochemical parameters in animals from the 0.1 and 0.3 mg/kg group, although the values are within the normal range of the species. There were no changes in the other evaluations performed. Together, these data indicate that prolonged exposure of rats to different doses of varenicline was not able to alter haematological, biochemical and anatomopathological parameters.
dc.description.firstpage305
dc.description.issuenumber3
dc.description.lastpage309
dc.description.volume122
dc.identifier.doi10.1111/bcpt.12913
dc.identifier.issn1742-7843
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/35559
dc.relation.ispartofBasic and Clinical Pharmacology and Toxicology
dc.rightsAcesso Aberto
dc.titleEvaluation of Prolonged Exposure to Varenicline in Adult Rats: Haematological, Biochemical and Anatomopathological Studies
dc.typeArtigo
local.scopus.citations5
local.scopus.eid2-s2.0-85031507281
local.scopus.subjectAdministration, Oral
local.scopus.subjectAnimals
local.scopus.subjectDose-Response Relationship, Drug
local.scopus.subjectDrinking
local.scopus.subjectEnergy Intake
local.scopus.subjectHeart
local.scopus.subjectHematopoiesis
local.scopus.subjectLiver
local.scopus.subjectMale
local.scopus.subjectMyocardium
local.scopus.subjectNicotinic Agonists
local.scopus.subjectOrgan Specificity
local.scopus.subjectRats, Wistar
local.scopus.subjectReproducibility of Results
local.scopus.subjectTobacco Use Cessation Products
local.scopus.subjectToxicity Tests, Subacute
local.scopus.subjectVarenicline
local.scopus.subjectWeight Gain
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85031507281&origin=inward
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