Effect of Low-Dose Progesterone on Glycemic Metabolism, Morphology and Function of Adipose Tissue and Pancreatic Islets in Diet-Induced Obese Female Mice

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dc.contributor.authorSantos M.P.
dc.contributor.authorCauduro L.F.R.
dc.contributor.authorFerreira M.M.
dc.contributor.authorMartucci L.F.
dc.contributor.authorVecchiatto B.
dc.contributor.authorVilas-Boas E.A.
dc.contributor.authorAmerico A.L.V.
dc.contributor.authorPereira R.O.
dc.contributor.authorRogero M.M.
dc.contributor.authorFiorino P.
dc.contributor.authorEvangelista F.S.
dc.contributor.authorAzevedo-Martins A.K.
dc.date.accessioned2024-03-12T19:10:57Z
dc.date.available2024-03-12T19:10:57Z
dc.date.issued2023
dc.description.abstract© 2023 The Author(s).Background: Obesity is a worldwide concern due to its global rapid expansion and remarkable impact on individual's health by predisposing to several other diseases. About twice as many women as men suffer from severe obesity and, in fact, there are stages in a woman's life when weight gain and adiposity can result in greater damage to health. For example, obesity triples the chance of a woman developing gestational diabetes. Many hormones promote the metabolic adaptations of pregnancy, including progesterone, whose role in female obesity is still not well known despite being involved in many physiological and pathological processes. Methods: Here we investigated whether progesterone treatment at low dose can worsen the glucose metabolism and the morpho functional aspects of adipose tissue and pancreas in obese females. Mice were assigned into four groups: normocaloric diet control (NO-CO), high-fat and -fructose diet control (HFF-CO), normocaloric diet plus progesterone (NO-PG) and high-fat and -fructose diet plus progesterone (HFF-PG) for 10 weeks. Infusion of progesterone (0.25 mg/kg/day) was done by osmotic minipump in the last 21 days of protocol. Results: Animals fed a hypercaloric diet exhibited obesity with increased body weight (p < 0.0001), adipocyte hypertrophy (p < 0.0001), hyperglycemia (p = 0.03), and glucose intolerance (p = 0.001). HFF-CO and HFF-PG groups showed lower adiponectin concentration (p < 0.0001) and glucose-stimulated insulin secretion (p = 0.03), without differences in islet size. Progesterone attenuated glucose intolerance in the HFFPG group (p = 0.03), however, did not change morphology or endocrine function of adipose tissue and pancreatic islets. Conclusions: Taken together, our results showed that low dose of progesterone does not worsen the effects of hypercaloric diet in glycemic metabolism, morphology and function of adipose tissue and pancreatic islets in female animals. These results may improve the understanding of the mechanisms underlying the pathogenesis of obesity in women and eventually open new avenues for therapeutic strategies and better comprehension of the interactions between progesterone effects and obesity.
dc.description.issuenumber11
dc.description.volume28
dc.identifier.doi10.31083/j.fbl2811312
dc.identifier.issn2768-6698
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/34147
dc.relation.ispartofFrontiers in Bioscience - Landmark
dc.rightsAcesso Aberto
dc.subject.otherlanguageadipose tissue
dc.subject.otherlanguagefemales
dc.subject.otherlanguagehypercaloric diet
dc.subject.otherlanguageobesity
dc.subject.otherlanguagepancreatic islets
dc.subject.otherlanguageprogesterone
dc.titleEffect of Low-Dose Progesterone on Glycemic Metabolism, Morphology and Function of Adipose Tissue and Pancreatic Islets in Diet-Induced Obese Female Mice
dc.typeArtigo
local.scopus.citations0
local.scopus.eid2-s2.0-85179646191
local.scopus.subjectAdipose Tissue
local.scopus.subjectAnimals
local.scopus.subjectDiet, High-Fat
local.scopus.subjectFemale
local.scopus.subjectFructose
local.scopus.subjectGlucose Intolerance
local.scopus.subjectHumans
local.scopus.subjectInsulin
local.scopus.subjectIslets of Langerhans
local.scopus.subjectMale
local.scopus.subjectMice
local.scopus.subjectMice, Inbred C57BL
local.scopus.subjectMice, Obese
local.scopus.subjectObesity
local.scopus.subjectPregnancy
local.scopus.subjectProgesterone
local.scopus.subjectWeight Gain
local.scopus.updated2024-10-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85179646191&origin=inward
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