Aerobic exercise training prevents kidney lipid deposition in mice fed a cafeteria diet

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dc.contributor.authorMuller C.R.
dc.contributor.authorAmerico A.L.V.
dc.contributor.authorFiorino P.
dc.contributor.authorEvangelista F.S.
dc.date.accessioned2024-03-12T23:56:25Z
dc.date.available2024-03-12T23:56:25Z
dc.date.issued2018
dc.description.abstract© 2018 Elsevier Inc.Aim: The objective of this study was to investigate the potential of aerobic exercise training (AET) to prevent kidney lipid accumulation and the contribution of renal metabolism to mediate this response. Main methods: Male C57BL/6J mice were assigned into groups CHOW-SED (chow diet, sedentary; n = 13), CHOW-TR (chow diet, trained; n = 13), CAF-SED (cafeteria diet, sedentary; n = 13) and CAF-TR (cafeteria diet, trained; n = 13). AET consisted in running sessions of 60 min at 60% of maximal speed conducted five days per week for eight weeks. Key findings: AET prevented weight gain in both trained groups. Food intake was not different among groups, however water intake, urine output, urine potassium and osmolarity were reduced in CAF-SED and CAF-TR groups. Kidney lipid deposition increased in CAF-SED (4.12 ± 0.5%/area) compared with CHOW-SED (1.7 ± 0.54%/area), and the AET prevented this increase in the CAF-TR group (2.1 ± 0.5%/area). The Bowman's capsule area decreased in CAF-SED and CAF-TR groups while the Bowman’ space reduced in CAF-SED compared to CHOW-SED group, which was prevented by AET in the CAF-TF group. We observed a 27% increase in the p-AMPK expression in CAF-TR compared to CHOW-SED group without differences in the SIRT-1, PGC1-α ACC and p-ACC. β-HAD activity increased in CAF-SED (43.9 ± 4.57 nmol·min−1·ug−1) and CAF-TR (44.7 ± 2.6 nmol·min−1·ug−1) groups compared to CHOW-SED (35.1 ± 2.9 nmol·min−1·ug−1) e CHOW-TR (36.6 ± 2.7 nmol·min−1·ug−1). Significance: AET prevented kidney lipid accumulation induced by cafeteria diet and this response was not associated with changes in the renal metabolic activity that favors lipid oxidation.
dc.description.firstpage140
dc.description.lastpage146
dc.description.volume211
dc.identifier.doi10.1016/j.lfs.2018.09.017
dc.identifier.issn1879-0631
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/35448
dc.relation.ispartofLife Sciences
dc.rightsAcesso Restrito
dc.subject.otherlanguageAerobic exercise training
dc.subject.otherlanguageKidney lipid deposition
dc.subject.otherlanguageOxidative metabolism
dc.titleAerobic exercise training prevents kidney lipid deposition in mice fed a cafeteria diet
dc.typeArtigo
local.scopus.citations9
local.scopus.eid2-s2.0-85053380258
local.scopus.subjectAnimals
local.scopus.subjectBody Weight
local.scopus.subjectDiet
local.scopus.subjectHyperlipidemias
local.scopus.subjectKidney
local.scopus.subjectLipid Metabolism
local.scopus.subjectLipids
local.scopus.subjectMale
local.scopus.subjectMice
local.scopus.subjectMice, Inbred C57BL
local.scopus.subjectPhysical Conditioning, Animal
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85053380258&origin=inward
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