Adverse childhood experience and rheumatic diseases

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dc.contributor.authorLuiz A.P.L.
dc.contributor.authorAntico H.A.
dc.contributor.authorSkare T.L.
dc.contributor.authorBoldt A.B.W.
dc.contributor.authorNisihara R.
dc.date.accessioned2024-03-12T23:56:46Z
dc.date.available2024-03-12T23:56:46Z
dc.date.issued2018
dc.description.abstract© 2018, International League of Associations for Rheumatology (ILAR).It has been suggested that the adaptive stress response may be disrupted by life adverse events such as childhood maltreatment. To investigate if the number of adverse childhood experiences (ACEs) increases susceptibility to systemic lupus erythematosus (SLE), spondyloarthritis (SpA), scleroderma (SSc), and rheumatoid arthritis (RA), we interviewed 315 patients with rheumatic disease (100 SLE; 40 SSc; 60 SpA; 115 RA) and 272 controls, using questions of the ACEs study questionnaire validated to ask about experiences of childhood abuse, negligence, domestic violence, and household dysfunctions. The questionnaire score ranges from zero (best result) to 8 (worst scenario). Patients and controls did not differ regarding the median number of ACEs (3 in both groups, patient IQR = 2.5–5 vs. control IQR = 2–5, p = 0.45). Among the patients, 63.8% (201/315) presented ACE score ≥ 3, compared with 59.9% (163/272) of the controls (p = 0.31). The proportion of patients with at least 3 ACEs did also not differ among those with different rheumatic diseases. Specifically, 64% (64/100) of those with SLE, 60% (24/40) of those with SSc, 60% (36/60) of those with SpA, and 66.9% (77/115) of those with RA reported at least 3 ACEs. There was also no difference between the distribution of ACE scores and number of individuals with ACEs ≥ 3 between patients with different rheumatic diseases and controls. Nevertheless, there was a trend for association between higher ACE score and susceptibility to RA (p = 0.06). In this setting, the occurrence of ACEs was not associated with susceptibility to rheumatic diseases in adulthood.
dc.description.firstpage2863
dc.description.issuenumber10
dc.description.lastpage2867
dc.description.volume37
dc.identifier.doi10.1007/s10067-018-4200-5
dc.identifier.issn1434-9949
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/35468
dc.relation.ispartofClinical Rheumatology
dc.rightsAcesso Restrito
dc.subject.otherlanguageAbuse
dc.subject.otherlanguageAdverse experience
dc.subject.otherlanguageAutoimmunity
dc.subject.otherlanguageChildhood
dc.subject.otherlanguageRheumatology
dc.titleAdverse childhood experience and rheumatic diseases
dc.typeArtigo
local.scopus.citations15
local.scopus.eid2-s2.0-85049677411
local.scopus.subjectAdult
local.scopus.subjectAdult Survivors of Child Adverse Events
local.scopus.subjectArthritis, Rheumatoid
local.scopus.subjectFemale
local.scopus.subjectHumans
local.scopus.subjectLupus Erythematosus, Systemic
local.scopus.subjectMale
local.scopus.subjectMiddle Aged
local.scopus.subjectRisk Factors
local.scopus.subjectScleroderma, Systemic
local.scopus.subjectSpondylarthritis
local.scopus.subjectSurveys and Questionnaires
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85049677411&origin=inward
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