Rosacea Topical Treatment and Care: From Traditional to New Drug Delivery Systems

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dc.contributor.authorPaiva-Santos A.C.
dc.contributor.authorGoncalves T.
dc.contributor.authorPeixoto D.
dc.contributor.authorPires P.C.
dc.contributor.authorVelsankar K.
dc.contributor.authorJha N.K.
dc.contributor.authorChavda V.P.
dc.contributor.authorMohammad I.S.
dc.contributor.authorCefali L.C.
dc.contributor.authorMazzola P.G.
dc.contributor.authorMascarenhas-Melo F.
dc.contributor.authorVeiga F.
dc.date.accessioned2024-03-12T19:08:57Z
dc.date.available2024-03-12T19:08:57Z
dc.date.issued2023
dc.description.abstract© 2023 The Authors. Published by American Chemical Society.Rosacea is a multifactorial chronic inflammatory dermatosis characterized by flushing, nontransient erythema, papules and pustules, telangiectasia, and phymatous alterations accompanied by itching, burning, or stinging, the pathophysiology of which is not yet fully understood. Conventional topical treatments usually show limited efficacy due to the physical barrier property of the skin that hinders skin penetration of the active ingredients, thereby hampering proper drug skin delivery and the respective therapeutic or cosmetic effects. New advances regarding the physiopathological understanding of the disease and the underlying mechanisms suggest the potential of new active ingredients as promising therapeutic and cosmetic approaches to this dermatosis. Additionally, the development of new drug delivery systems for skin delivery, particularly the potential of nanoparticles for the topical treatment and care of rosacea, has been described. Emphasis has been placed on their reduced nanometric size, which contributes to a significant improvement in the attainment of targeted skin drug delivery. In addition to the exposition of the known pathophysiology, epidemiology, diagnosis, and preventive measures, this Review covers the topical approaches used in the control of rosacea, including skin care, cosmetics, and topical therapies, as well as the future perspectives on these strategies.
dc.description.firstpage3804
dc.description.issuenumber8
dc.description.lastpage3828
dc.description.volume20
dc.identifier.doi10.1021/acs.molpharmaceut.3c00324
dc.identifier.issn1543-8392
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/34043
dc.relation.ispartofMolecular Pharmaceutics
dc.rightsAcesso Aberto
dc.subject.otherlanguageCosmetic
dc.subject.otherlanguageDrug Delivery System
dc.subject.otherlanguageNanoparticle
dc.subject.otherlanguageRosacea
dc.subject.otherlanguageSkin
dc.subject.otherlanguageTherapy
dc.titleRosacea Topical Treatment and Care: From Traditional to New Drug Delivery Systems
dc.typeArtigo de revisão
local.scopus.citations11
local.scopus.eid2-s2.0-85166626145
local.scopus.subjectAdministration, Topical
local.scopus.subjectChronic Disease
local.scopus.subjectDermatologic Agents
local.scopus.subjectHumans
local.scopus.subjectRosacea
local.scopus.updated2024-12-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85166626145&origin=inward
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