Direct antiglobulin (Coombs) test in systemic lupus erythematosus patients

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dc.contributor.authorSkare T.
dc.contributor.authorPicelli L.
dc.contributor.authordos Santos T.A.G.
dc.contributor.authorNisihara R.
dc.date.accessioned2024-03-13T00:48:48Z
dc.date.available2024-03-13T00:48:48Z
dc.date.issued2017
dc.description.abstract© 2017, International League of Associations for Rheumatology (ILAR).The objective of the study is to study the positivity of Coombs test or direct antiglobulin test (DAT) in systemic lupus erythematosus (SLE) patients and its relationship with disease’s clinical and serological profile. Retrospective study of 373 SLE patients seen at single Rheumatology Unit. Epidemiological data (age, gender, age at disease onset, auto declared ethnic background and tobacco use), clinical (malar rash, photosensitivity, oral ulcers, discoid lesions, serositis, glomerulonephritis, convulsions, psychosis, hemolytic anemia, leukopenia, lymphocytopenia and arthritis), and serological profile (anti ds DNA, anti Ro/SS-A; anti La/SS-B, Anti RNP, Anti Sm, aCl (anticardiolipin) IgG, aCl Ig M, LA or lupus anticoagulant, rheumatoid factor and direct Coombs) were collected. Patients with a positive DAT were compared with the negatives. DAT was positive in 12.8% of patients and 54.3% of them had hemolytic anemia. In univariate analysis, a positive DAT was associated with hemolytic anemia (p < 0.0001), secondary antiphospholipid antibody syndrome (p = 0.02), anticardiolipin IgG (p < 0.0001), lupus anticoagulant (p = 0.05), positive VDRL (p = 0.004), anti-RNP (p < 0.0001), anti-Sm (p = 0.002), and anti-La (p = 0.02). Logistic regression revealed that hemolytic anemia, anti-RNP and anti-LA were independently associated with positive DAT. DAT was positive in 12.8% of SLE studied sample and 54.3% of them had hemolytic anemia. This test was independently associated with hemolytic anemia, anti-RNP and anti-La antibodies.
dc.description.firstpage2141
dc.description.issuenumber9
dc.description.lastpage2144
dc.description.volume36
dc.identifier.doi10.1007/s10067-017-3778-3
dc.identifier.issn1434-9949
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/35726
dc.relation.ispartofClinical Rheumatology
dc.rightsAcesso Restrito
dc.subject.otherlanguageAntiphospholipid antibody syndrome
dc.subject.otherlanguageCoombs test
dc.subject.otherlanguageDirect antiglobulin test
dc.subject.otherlanguageHemolytic anemia
dc.subject.otherlanguageSystemic lupus erythematosus
dc.titleDirect antiglobulin (Coombs) test in systemic lupus erythematosus patients
dc.typeArtigo
local.scopus.citations13
local.scopus.eid2-s2.0-85026514507
local.scopus.subjectAdult
local.scopus.subjectAnemia, Hemolytic, Autoimmune
local.scopus.subjectAntibodies, Antinuclear
local.scopus.subjectAntiphospholipid Syndrome
local.scopus.subjectFemale
local.scopus.subjectHumans
local.scopus.subjectLogistic Models
local.scopus.subjectLupus Erythematosus, Systemic
local.scopus.subjectMale
local.scopus.subjectMiddle Aged
local.scopus.subjectRetrospective Studies
local.scopus.subjectThrombocytopenia
local.scopus.subjectYoung Adult
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85026514507&origin=inward
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