Clinical and subclinical maternal hypothyroidism and their effects on neurodevelopment, behavior and cognition

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dc.contributor.authorBatistuzzo A.
dc.contributor.authorRibeiro M.O.
dc.date.accessioned2024-03-12T23:50:19Z
dc.date.available2024-03-12T23:50:19Z
dc.date.issued2020
dc.description.abstract© 2020, Sociedade Brasileira de Endocrinologia e Metabologia. All rights reserved.Clinical and subclinical hypothyroidism are the most common hormonal dysfunctions during pregnancy. Insufficient maternal thyroid hormones (THs) in the early stages of pregnancy can lead to severe impairments in the development of the central nervous system becauseTHs are critical to central nervous system development. In the fetus and after birth, THs participate in neurogenic processes, cell differentiation, neuronal activation, axonal growth, dendritic arborization, synaptogenesis and myelination. Although treatment is simple and effective, approximately 30% of pregnant women in Brazil with access to prenatal care have their first consultation after the first trimester of pregnancy, and any delay in diagnosis and resulting treatment delay may lead to cognitive impairment in children. This review summarizes the effects of clinical and subclinical hypothyroidism on fetal neurodevelopment, behavior and cognition in humans and rodents. Arch Endocrinol Metab. 2020;64(1):89-95.
dc.description.firstpage89
dc.description.issuenumber1
dc.description.lastpage95
dc.description.volume64
dc.identifier.doi10.20945/2359-3997000000201
dc.identifier.issn2359-4292
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/35113
dc.relation.ispartofArchives of Endocrinology and Metabolism
dc.rightsAcesso Aberto
dc.subject.otherlanguageBehavior
dc.subject.otherlanguageCognition
dc.subject.otherlanguageHypothyroidism
dc.subject.otherlanguageOffspring
dc.subject.otherlanguagePregnancy
dc.titleClinical and subclinical maternal hypothyroidism and their effects on neurodevelopment, behavior and cognition
dc.typeArtigo de revisão
local.scopus.citations27
local.scopus.eid2-s2.0-85081998265
local.scopus.subjectAnimals
local.scopus.subjectBrain
local.scopus.subjectCognitive Dysfunction
local.scopus.subjectFemale
local.scopus.subjectHumans
local.scopus.subjectHypothyroidism
local.scopus.subjectMaternal-Fetal Exchange
local.scopus.subjectMice
local.scopus.subjectPregnancy
local.scopus.subjectPregnancy Complications
local.scopus.subjectPregnancy Outcome
local.scopus.subjectPregnancy Trimesters
local.scopus.subjectPrenatal Exposure Delayed Effects
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85081998265&origin=inward
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