Prognostic evaluation of severe sepsis and septic shock: Procalcitonin clearance vs δ Sequential Organ Failure Assessment

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dc.contributor.authorde Azevedo J.R.A.
dc.contributor.authorTorres O.J.M.
dc.contributor.authorBeraldi R.A.
dc.contributor.authorRibas C.A.P.M.
dc.contributor.authorMalafaia O.
dc.date.accessioned2024-03-13T00:57:49Z
dc.date.available2024-03-13T00:57:49Z
dc.date.issued2015
dc.description.abstract© 2014 Elsevier Inc.Purpose: The purpose of the study is to compare the clearance of procalcitonin (PCT-c) in the first 24 and 48 hours of treatment of severe sepsis and septic shock with another early prognostic marker represented by the 48-hour δ Sequential Organ Failure Assessment (SOFA). Materials and methods: Prospective, observational cohort study conducted in a general intensive care unit including patients with severe sepsis and septic shock. The PCT-c was determined at the diagnosis of sepsis and after 24 and 48 hours. The SOFA score was determined at the time of intensive care unit admission and after 48 hours. Results: One hundred thirty adult patients with severe sepsis and septic shock were studied over an 18-month period. The 24- and 48-hour PTC-c scores were significantly higher in survivors (P < .0001). In nonsurvivors, the initial SOFA was significantly higher, and the 48-hour δ SOFA was significantly smaller (P = .01). The area under the receiver operating characteristic curve was 0.68 for δ SOFA and 0.76 for 24- and 48-hour PCT-c. Conclusions: The 48-hour δ SOFA score and the clearance of 24- and 48-hour PCT are useful markers of prognosis in patients with severe sepsis and septic shock. A decrease in PCT-c in the first 24 hours of treatment should prompt the reassessment of the appropriateness and adequacy of treatment.
dc.description.firstpage219.e9
dc.description.issuenumber1
dc.description.lastpage219.e12
dc.description.volume30
dc.identifier.doi10.1016/j.jcrc.2014.08.018
dc.identifier.issn1557-8615
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/36233
dc.relation.ispartofJournal of Critical Care
dc.rightsAcesso Restrito
dc.subject.otherlanguageBiomarker
dc.subject.otherlanguageProcalcitonin
dc.subject.otherlanguagePrognosis
dc.subject.otherlanguageSeptic shock
dc.subject.otherlanguageSevere sepsis
dc.subject.otherlanguageSOFA score
dc.titlePrognostic evaluation of severe sepsis and septic shock: Procalcitonin clearance vs δ Sequential Organ Failure Assessment
dc.typeArtigo
local.scopus.citations45
local.scopus.eid2-s2.0-84920593314
local.scopus.subjectAdult
local.scopus.subjectAged
local.scopus.subjectArea Under Curve
local.scopus.subjectBiological Markers
local.scopus.subjectCalcitonin
local.scopus.subjectFemale
local.scopus.subjectHumans
local.scopus.subjectIntensive Care Units
local.scopus.subjectMale
local.scopus.subjectMiddle Aged
local.scopus.subjectOrgan Dysfunction Scores
local.scopus.subjectPrognosis
local.scopus.subjectProspective Studies
local.scopus.subjectProtein Precursors
local.scopus.subjectROC Curve
local.scopus.subjectSepsis
local.scopus.subjectShock, Septic
local.scopus.subjectSurvivors
local.scopus.subjectTime Factors
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84920593314&origin=inward
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