Exercise training prevents cardiovascular derangements induced by fructose overload in developing rats

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dc.contributor.authorFarah D.
dc.contributor.authorNunes J.
dc.contributor.authorSartori M.
dc.contributor.authorDa Silva Dias D.
dc.contributor.authorSirvente R.
dc.contributor.authorSilva M.B.
dc.contributor.authorFiorino P.
dc.contributor.authorMorris M.
dc.contributor.authorLlesuy S.
dc.contributor.authorFarah V.
dc.contributor.authorIrigoyen M.-C.
dc.contributor.authorDe Angelis K.
dc.date.accessioned2024-03-13T00:51:49Z
dc.date.available2024-03-13T00:51:49Z
dc.date.issued2016
dc.description.abstract© 2016 Farah et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.The risks of chronic diseases associated with the increasing consumption of fructose-laden foods are amplified by the lack of regular physical activity and have become a serious public health issue worldwide. Moreover, childhood eating habits are strongly related to metabolic syndrome in adults. Thus, we aimed to investigate the preventive role of exercise training undertaken concurrently with a high fructose diet on cardiac function, hemodynamics, cardiovascular autonomic modulation and oxidative stress in male rats after weaning. Male Wistar rats were divided into 4 groups (n = 8/group): Sedentary control (SC), Trained control (TC), Sedentary Fructose (SF) and Trained Fructose (TF). Training was performed on a treadmill (8 weeks, 40-60% of maximum exercise test). Evaluations of cardiac function, hemodynamics, cardiovascular autonomic modulation and oxidative stress in plasma and in left ventricle (LV) were performed. Chronic fructose overload induced glucose intolerance and an increase in white adipose tissue (WAT) weight, in myocardial performance index (MPI) (SF:0.42±0.04 vs. SC:0.24±0.05) and in arterial pressure (SF:122±3 vs. SC:113±1 mmHg) associated with increased cardiac and vascular sympathetic modulation. Fructose also induced unfavorable changes in oxidative stress profile (plasmatic protein oxidation- SF:3.30±0.09 vs. SC:1.45±0.08 nmol/mg prot; and LV total antioxidant capacity (TRAP)-SF: 2.5±0.5 vs. SC:12.7±1.7 uM trolox). The TF group showed reduced WAT, glucose intolerance, MPI (0.35±0.04), arterial pressure (118±2mmHg), sympathetic modulation, plasmatic protein oxidation and increased TRAP when compared to SF group. Therefore, our findings indicate that cardiometabolic dysfunctions induced by fructose overload early in life may be prevented by moderate aerobic exercise training.
dc.description.issuenumber12
dc.description.volume11
dc.identifier.doi10.1371/journal.pone.0167291
dc.identifier.issn1932-6203
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/35896
dc.relation.ispartofPLoS ONE
dc.rightsAcesso Aberto
dc.titleExercise training prevents cardiovascular derangements induced by fructose overload in developing rats
dc.typeArtigo
local.scopus.citations14
local.scopus.eid2-s2.0-85002675484
local.scopus.subjectAnimals
local.scopus.subjectBlood Pressure
local.scopus.subjectCardiovascular System
local.scopus.subjectFructose
local.scopus.subjectHeart Rate
local.scopus.subjectMale
local.scopus.subjectOxidative Stress
local.scopus.subjectPhysical Conditioning, Animal
local.scopus.subjectRats
local.scopus.subjectRats, Wistar
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85002675484&origin=inward
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