Square Wave Voltammetric Determination of 8-Hydroxyquinoline-2-Carboxaldehyde Isonicotinoyl Hydrazone (INHHQ), a Promising Metal-Protein Attenuating Compound for the Treatment of Alzheimer’s Disease, Using a Multiwalled Carbon Nanotube (MWCNT) Modified Glassy Carbon Electrode (GCE)

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dc.contributor.authorPedrozo-Penafiel M.J.
dc.contributor.authorFalco A.D.
dc.contributor.authorMiranda-Andrades J.R.
dc.contributor.authorAlmeida J.M.S.
dc.contributor.authorLarrude D.G.
dc.contributor.authorRey N.A.
dc.contributor.authorAucelio R.Q.
dc.date.accessioned2024-03-12T23:46:51Z
dc.date.available2024-03-12T23:46:51Z
dc.date.issued2020
dc.description.abstract© 2020, © 2020 Taylor & Francis Group, LLC.An analytical method for the determination of 8-hydroxyquinoline-2-carboxaldehyde isonicotinoyl hydrazone (INHHQ) is reported for the first time. The electrochemical method involving INHHQ was performed at a glassy carbon (GC) electrode modified with multiwalled carbon nanotubes (MWCNTs). The GC-MWCNTs promoted a significantly large enhancement in the Faradaic current employing square wave voltammetry (SWV) to determine INHHQ in the fortified extracts of the brain from Wistar rats. In addition, the MWCNTs increased the active electrode area, produced an electro-catalytic effect and provided significantly faster electron transfer. The quantification of INHHQ was made by the use of a supporting electrolyte consisting of Britton-Robinson (BR) buffer at a concentration of 0.02 mol L−1 and a pH of 11.0 in 0.25 mol L−1 KCl. The quantitative assay using square wave voltammetry was achieved by the serial addition of a standard into the electrochemical cell containing the sample. The limit of detection (LOD) for the protocol was equal to 0.25 µg mL−1 (0.85 µmol L−1). A procedure involving thin-layer chromatography (TLC) was employed in order to improve the selectivity required to determine INHHQ. The recoveries of the analyte in brain tissue from Wistar rats were statistically comparable to the values obtained by a high-performance liquid chromatography (HPLC) protocol.
dc.description.firstpage2337
dc.description.issuenumber14
dc.description.lastpage2354
dc.description.volume53
dc.identifier.doi10.1080/00032719.2020.1741603
dc.identifier.issn0003-2719
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/34918
dc.relation.ispartofAnalytical Letters
dc.rightsAcesso Restrito
dc.subject.otherlanguage8-hydroxyquinoline-2-carboxaldehyde isonicotinoyl hydrazone (INHHQ)
dc.subject.otherlanguagebrain tissue
dc.subject.otherlanguageglassy carbon electrode (GCE)
dc.subject.otherlanguagemulti-walled carbon nanotubes (MWCNTs)
dc.subject.otherlanguagesquare-wave voltammetry
dc.titleSquare Wave Voltammetric Determination of 8-Hydroxyquinoline-2-Carboxaldehyde Isonicotinoyl Hydrazone (INHHQ), a Promising Metal-Protein Attenuating Compound for the Treatment of Alzheimer’s Disease, Using a Multiwalled Carbon Nanotube (MWCNT) Modified Glassy Carbon Electrode (GCE)
dc.typeArtigo
local.scopus.citations1
local.scopus.eid2-s2.0-85081715915
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85081715915&origin=inward
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