A randomized, double-blind clinical trial on the efficacy of cortical direct current stimulation for the treatment of major depression

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dc.contributor.authorBoggio P.S.
dc.contributor.authorRigonatti S.P.
dc.contributor.authorRibeiro R.B.
dc.contributor.authorMyczkowski M.L.
dc.contributor.authorNitsche M.A.
dc.contributor.authorPascual-Leone A.
dc.contributor.authorFregni F.
dc.date.accessioned2024-03-13T01:37:41Z
dc.date.available2024-03-13T01:37:41Z
dc.date.issued2008
dc.description.abstractPreliminary findings suggest that transcranial direct current stimulation (tDCS) can have antidepressant effects. We sought to test this further in a parallel-group, double-blind clinical trial with 40 patients with major depression, medication-free randomized into three groups of treatment: anodal tDCS of the left dorsolateral prefrontal cortex (active group - 'DLPFC'); anodal tDCS of the occipital cortex (active control group - 'occipital') and sham tDCS (placebo control group - 'sham'). tDCS was applied for 10 sessions during a 2-wk period. Mood was evaluated by a blinded rater using the Hamilton Depression Rating Scale (HDRS) and Beck Depression Inventory (BDI). The treatment was well tolerated with minimal side-effects that were distributed equally across all treatment groups. We found significantly larger reductions in depression scores after DLPFC tDCS [HDRS reduction of 40.4% (±25.8%)] compared to occipital [HDRS reduction of 21.3% (±12.9%)] and sham tDCS [HDRS reduction of 10.4% (±36.6%)]. The beneficial effects of tDCS in the DLPFC group persisted for 1 month after the end of treatment. Our findings support further investigation on the effects of this novel potential therapeutic approach - tDCS - for the treatment of major depression. © 2007 Collegium Internationale Neuropsychopharmacologicum.
dc.description.firstpage249
dc.description.issuenumber2
dc.description.lastpage254
dc.description.volume11
dc.identifier.doi10.1017/S1461145707007833
dc.identifier.issn1461-1457
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/37528
dc.relation.ispartofInternational Journal of Neuropsychopharmacology
dc.rightsAcesso Aberto
dc.subject.otherlanguageBrain stimulation
dc.subject.otherlanguageElectrical stimulation
dc.subject.otherlanguageMajor depression
dc.subject.otherlanguagePrefrontal cortex
dc.subject.otherlanguageTranscranial direct current stimulation
dc.titleA randomized, double-blind clinical trial on the efficacy of cortical direct current stimulation for the treatment of major depression
dc.typeArtigo
local.scopus.citations456
local.scopus.eid2-s2.0-38949211801
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=38949211801&origin=inward
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