Changes in glucose and glutamine lymphocyte metabolisms induced by type i interferon α

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dc.contributor.authorBacurau R.F.P.
dc.contributor.authorNavarro F.
dc.contributor.authorBacurau A.V.N.
dc.contributor.authorVanzelli A.
dc.contributor.authorMeneguello-Coutinho M.
dc.contributor.authorUchida M.C.
dc.contributor.authorMoraes M.R.
dc.contributor.authorAlmeida S.S.
dc.contributor.authorWasinski F.
dc.contributor.authorBarros C.C.
dc.contributor.authorWurtele M.
dc.contributor.authorArajo R.C.
dc.contributor.authorCosta Rosa L.F.B.
dc.date.accessioned2024-03-13T01:30:25Z
dc.date.available2024-03-13T01:30:25Z
dc.date.issued2010
dc.description.abstractIn lymphocytes (LY), the well-documented antiproliferative effects of IFN- are associated with inhibition of protein synthesis, decreased amino acid incorporation, and cell cycle arrest. However, the effects of this cytokine on the metabolism of glucose and glutamine in these cells have not been well investigated. Thus, mesenteric and spleen LY of male Wistar rats were cultured in the presence or absence of IFN-, and the changes on glucose and glutamine metabolisms were investigated. The reduced proliferation of mesenteric LY was accompanied by a reduction in glucose total consumption (35), aerobic glucose metabolism (55), maximal activity of glucose-6-phosphate dehydrogenase (49), citrate synthase activity (34), total glutamine consumption (30), aerobic glutamine consumption (20.3) and glutaminase activity (56). In LY isolated from spleen, IFN also reduced the proliferation and impaired metabolism. These data demonstrate that in LY, the antiproliferative effects of IFN are associated with a reduction in glucose and glutamine metabolisms. © 2010 Francisco Navarro et al.
dc.description.volume2010
dc.identifier.doi10.1155/2010/364290
dc.identifier.issn0962-9351
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/37123
dc.relation.ispartofMediators of Inflammation
dc.rightsAcesso Aberto
dc.titleChanges in glucose and glutamine lymphocyte metabolisms induced by type i interferon α
dc.typeArtigo
local.scopus.citations6
local.scopus.eid2-s2.0-79952214700
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79952214700&origin=inward
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