Supporting Clinical COVID-19 Diagnosis with Routine Blood Tests Using Tree-Based, Entropy-Structured Self-Organizing Maps

dc.contributor.authorSargiani V.
dc.contributor.authorDe Souza A.A.
dc.contributor.authorDe Almeida D.C.
dc.contributor.authorBarcelos T.S.
dc.contributor.authorMunoz R.
dc.contributor.authorDa Silva L.A.
dc.date.accessioned2024-03-12T19:15:04Z
dc.date.available2024-03-12T19:15:04Z
dc.date.issued2022
dc.description.abstract© 2022 by the authors. Licensee MDPI, Basel, Switzerland.Data classification is an automatic or semi-automatic process that, utilizing artificial intelligence algorithms, learns the variable and class relationships of a dataset for use a posteriori in situations where the class result is unknown. For many years, work on this topic has been aimed at increasing the hit rates of algorithms. However, when the problem is restricted to applications in healthcare, besides the concern with performance, it is also necessary to design algorithms whose results are understandable by the specialists responsible for making the decisions. Among the prob-lems in the field of medicine, a current focus is related to COVID-19: AI algorithms may contribute to early diagnosis. Among the available COVID-19 data, the blood test is a typical procedure per-formed when the patient seeks the hospital, and its use in the diagnosis allows reducing the need for other diagnostic tests that can impact the detection time and add to costs. In this work, we propose using self-organizing map (SOM) to discover attributes in blood test examinations that are relevant for COVID-19 diagnosis. We applied SOM and an entropy calculation in the definition of a hierarchical, semi-supervised and explainable model named TESSOM (tree-based entropy-structured self-organizing maps), in which the main feature is enhancing the investigation of groups of cases with high levels of class overlap, as far as the diagnostic outcome is concerned. Framing the TESSOM algorithm in the context of explainable artificial intelligence (XAI) makes it possible to explain the results to an expert in a simplified way. It is demonstrated in the paper that the use of the TESSOM algorithm to identify attributes of blood tests can help with the identification of COVID-19 cases. It providing a performance increase in 1.489% in multiple scenarios when analyzing 2207 cases from three hospitals in the state of São Paulo, Brazil. This work is a starting point for researchers to identify relevant attributes of blood tests for COVID-19 and to support the diagnosis of other diseases.
dc.description.issuenumber10
dc.description.volume12
dc.identifier.doi10.3390/app12105137
dc.identifier.issn2076-3417
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/34368
dc.relation.ispartofApplied Sciences (Switzerland)
dc.rightsAcesso Aberto
dc.subject.otherlanguageCOVID-19
dc.subject.otherlanguagedata mining
dc.subject.otherlanguageentropy
dc.subject.otherlanguageself-organizing maps
dc.subject.otherlanguageTESSOM
dc.subject.otherlanguagevisual support
dc.subject.otherlanguageXAI
dc.titleSupporting Clinical COVID-19 Diagnosis with Routine Blood Tests Using Tree-Based, Entropy-Structured Self-Organizing Maps
dc.typeArtigo
local.scopus.citations4
local.scopus.eid2-s2.0-85131303673
local.scopus.updated2024-06-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85131303673&origin=inward
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