High positivity of anti-CCP antibodies in patients with Down syndrome

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dc.contributor.authorNisihara R.M.
dc.contributor.authorSkare T.L.
dc.contributor.authorSilva M.B.G.
dc.contributor.authorMessias-Reason I.T.
dc.contributor.authorOliveira N.P.
dc.contributor.authorFiedler P.T.
dc.contributor.authorUtiyama S.R.R.
dc.date.accessioned2024-03-13T01:39:16Z
dc.date.available2024-03-13T01:39:16Z
dc.date.issued2007
dc.description.abstractThe aim of the present study was to evaluate the prevalence of anti-cyclic citrullinated peptide (CCP) antibodies in patients with Down's syndrome (DS) previously tested for IgM rheumatoid factor (RF) and to correlate the results with clinical findings. Eighty-eight patients with DS previously tested for IgM-RF were divided into two groups matched for sex and age. Group A consists of 42 RF positive patients and group B of 44 RF negative patients. The presence of anti-CCP antibody was determined using a second-generation enzyme-linked immunosorbent assay. A total of 52.3% (45/86) of DS patients were positive for anti-CCP antibodies. Twenty-four patients (57.1%) of the RF positive group and 21 (47.7%) of the RF negative group presented anti-CCP circulating antibodies. The concordance between both tests was 54.6%. None of the patients had clinical evidence of rheumatoid arthritis or juvenile idiopathic arthritis. Although a high prevalence of anti-CCP antibodies was observed in DS patients, no association has been found presently with clinical disease. Careful follow-up of these patients will be necessary to clarify the real significance of these findings. © Clinical Rheumatology 2007.
dc.description.firstpage2031
dc.description.issuenumber12
dc.description.lastpage2035
dc.description.volume26
dc.identifier.doi10.1007/s10067-007-0606-1
dc.identifier.issn0770-3198
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/37615
dc.relation.ispartofClinical Rheumatology
dc.rightsAcesso Restrito
dc.subject.otherlanguageAnti-CCP antibodies
dc.subject.otherlanguageDown syndrome
dc.subject.otherlanguageRheumatoid arthritis
dc.subject.otherlanguageRheumatoid factor
dc.titleHigh positivity of anti-CCP antibodies in patients with Down syndrome
dc.typeArtigo
local.scopus.citations19
local.scopus.eid2-s2.0-36248957581
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=36248957581&origin=inward
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