Assessing an imidazolium salt's performance as antifungal agent on a mouthwash formulation

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dc.contributor.authorBergamo V.Z.
dc.contributor.authorDonato R.K.
dc.contributor.authorNemitz M.C.
dc.contributor.authorAcasigua G.A.X.
dc.contributor.authorSelukar B.S.
dc.contributor.authorLopes W.
dc.contributor.authorDalla Lana D.F.
dc.contributor.authorTeixeira M.L.
dc.contributor.authorTeixeira H.F.
dc.contributor.authorSchrekker H.S.
dc.contributor.authorFuentefria A.M.
dc.date.accessioned2024-03-13T00:51:52Z
dc.date.available2024-03-13T00:51:52Z
dc.date.issued2016
dc.description.abstract© 2016 The Society for Applied MicrobiologyAims: This study demonstrates the development of a mouthwash formulation containing the imidazolium salt (IMS) 1-n-hexadecyl-3-methylimidazolium chloride (C16MImCl), considering its stability and efficacy against Candida sp. Biofilm formation. Methods and Results: A variety of in vitro test methods were applied, assessing contaminated acrylic resin strip specimens before and after applying the mouthwash formulations. The formulation using C16MImCl presented a similar antibiofilm activity to cetylpyridinium chloride one and a commercial mouthwash, but at a 10 times lower concentration. Scanning electron microscopy imaging demonstrated that the selected mouthwash preparation fully destroys the biofilm cells, while with the hypoallergenicity test no irritant effect was observed in ex vivo model. Conclusions: The results presented herein indicate a high potential for imidazolium salts application as mouthwash agents that can eliminate Candida biofilm growth at very low concentrations. Significance and Impact of the Study: This study demonstrates a new and effective antibiofilm formulation containing the IMS C16MImCl. These findings suggest the IMS’ use as mouthwash formulations active ingredient against Candida biofilms on oral surfaces, as it outperforms the often used cetylpyridinium chloride at a 10 times lower concentration.
dc.description.firstpage1558
dc.description.issuenumber6
dc.description.lastpage1567
dc.description.volume121
dc.identifier.doi10.1111/jam.13283
dc.identifier.issn1365-2672
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/35898
dc.relation.ispartofJournal of Applied Microbiology
dc.rightsAcesso Restrito
dc.subject.otherlanguageantibiofilm
dc.subject.otherlanguageantifungal
dc.subject.otherlanguageCandida
dc.subject.otherlanguageimidazolium salts
dc.subject.otherlanguagemouthwash
dc.titleAssessing an imidazolium salt's performance as antifungal agent on a mouthwash formulation
dc.typeArtigo
local.scopus.citations8
local.scopus.eid2-s2.0-84995700076
local.scopus.subjectAntibiofilms
local.scopus.subjectAntifungals
local.scopus.subjectBiofilm formation
local.scopus.subjectCandida sp
local.scopus.subjectCetylpyridinium Chloride
local.scopus.subjectImidazolium salt
local.scopus.subjectLow concentrations
local.scopus.subjectMethylimidazolium chloride
local.scopus.subjectMouthwash
local.scopus.subjectPerformance
local.scopus.subjectAntifungal Agents
local.scopus.subjectBiofilms
local.scopus.subjectCandida
local.scopus.subjectImidazoles
local.scopus.subjectMouthwashes
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84995700076&origin=inward
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