Cognitive control therapy and transcranial direct current stimulation for depression: A randomized, double-blinded, controlled trial

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dc.contributor.authorBrunoni A.R.
dc.contributor.authorBoggio P.S.
dc.contributor.authorDe Raedt R.
dc.contributor.authorBensenor I.M.
dc.contributor.authorLotufo P.A.
dc.contributor.authorNamur V.
dc.contributor.authorValiengo L.C.L.
dc.contributor.authorVanderhasselt M.A.
dc.date.accessioned2024-03-13T01:00:28Z
dc.date.available2024-03-13T01:00:28Z
dc.date.issued2014
dc.description.abstractBackground Based on findings that major depressive disorder (MDD) is associated to decreased dorsolateral prefrontal cortical (DLPFC) activity; interventions that increase DLPFC activity might theoretically present antidepressant effects. Two of them are cognitive control therapy (CCT), a neurocognitive intervention that uses computer-based working memory exercises, and transcranial direct current stimulation (tDCS), which delivers weak, electric direct currents over the scalp. Methods We investigated whether tDCS enhanced the effects of CCT in a double-blind trial, in which participants were randomized to sham tDCS and CCT (n=17) vs. active tDCS and CCT (n=20). CCT and tDCS were applied for 10 consecutive workdays. Clinicaltrials.gov identifier: NCT01434836. Results Both CCT alone and combined with tDCS ameliorated depressive symptoms after the acute treatment period and at follow-up, with a response rate of approximately 25%. Older patients and those who presented better performance in the task throughout the trial (possibly indicating greater engagement and activation of the DLPFC) had greater depression improvement in the combined treatment group. Limitations Our exploratory findings should be further confirmed in prospective controlled trials. Discussion CCT and tDCS combined might be beneficial for older depressed patients, particularly for those who have cognitive resources to adequately learn and improve task performance over time. This combined therapy might be specifically relevant in this subgroup that is more prone to present cognitive decline and prefrontal cortical atrophy. © 2014 Elsevier B.V.
dc.description.firstpage43
dc.description.lastpage49
dc.description.volume162
dc.identifier.doi10.1016/j.jad.2014.03.026
dc.identifier.issn1573-2517
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/36381
dc.relation.ispartofJournal of Affective Disorders
dc.rightsAcesso Restrito
dc.subject.otherlanguageControl cognitive therapy
dc.subject.otherlanguageGeriatric depression
dc.subject.otherlanguageMajor depressive disorder
dc.subject.otherlanguageNon-invasive brain stimulation
dc.subject.otherlanguageRandomized clinical trial
dc.subject.otherlanguageTranscranial direct current stimulation
dc.titleCognitive control therapy and transcranial direct current stimulation for depression: A randomized, double-blinded, controlled trial
dc.typeArtigo
local.scopus.citations172
local.scopus.eid2-s2.0-84898649152
local.scopus.subjectAdolescent
local.scopus.subjectAdult
local.scopus.subjectAged
local.scopus.subjectCognition
local.scopus.subjectCognitive Therapy
local.scopus.subjectCombined Modality Therapy
local.scopus.subjectDepressive Disorder, Major
local.scopus.subjectDouble-Blind Method
local.scopus.subjectElectric Stimulation Therapy
local.scopus.subjectFemale
local.scopus.subjectHumans
local.scopus.subjectMale
local.scopus.subjectMiddle Aged
local.scopus.subjectProspective Studies
local.scopus.subjectYoung Adult
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84898649152&origin=inward
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