Effects of morin on snake venom phospholipase A2 (PLA 2)

Página do item simplificado
dc.contributor.authorIglesias C.V.
dc.contributor.authorAparicio R.
dc.contributor.authorRodrigues-Simioni L.
dc.contributor.authorCamargo E.A.
dc.contributor.authorAntunes E.
dc.contributor.authorMarangoni S.
dc.contributor.authorToyama D.D.O.
dc.contributor.authorBeriam L.O.S.
dc.contributor.authorMonteiro H.S.A.
dc.contributor.authorToyama M.H.
dc.date.accessioned2024-03-13T01:43:40Z
dc.date.available2024-03-13T01:43:40Z
dc.date.issued2005
dc.description.abstractFlavonoids are potent anti-inflammatory compounds isolated from several plant extracts, and have been used experimentally against inflammatory processes. In this work, a PLA2 isolated from the Crotalus durissus cascavella venom and rat paw oedema were used as a model to study the effect of flavonoids on PLA2. We observed that a treatment of PLA2 with morin induces several modifications in the aromatic amino acids, with accompanying changes in its amino acid composition. In addition, results from circular dichroism spectroscopy and UV scanning revealed important structural modifications. Concomitantly, a considerable decrease in the enzymatic and antibacterial activities was observed, even though anti-inflammatory and neurotoxic activities were not affected. These apparent controversial results may be an indication that PLA2 possess a second pharmacological site which does not affect or depend on the enzymatic activity. © 2005 Elsevier Ltd. All rights reserved.
dc.description.firstpage751
dc.description.issuenumber7
dc.description.lastpage758
dc.description.volume46
dc.identifier.doi10.1016/j.toxicon.2005.07.017
dc.identifier.issn0041-0101
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/37854
dc.relation.ispartofToxicon
dc.rightsAcesso Restrito
dc.subject.otherlanguageAntibacterial activity
dc.subject.otherlanguageCircular dichroism spectroscopy
dc.subject.otherlanguageCrotalus durissus cascavella
dc.subject.otherlanguageFlavonoids
dc.subject.otherlanguageMorin
dc.subject.otherlanguageNeurotoxic
dc.subject.otherlanguagePLA2
dc.titleEffects of morin on snake venom phospholipase A2 (PLA 2)
dc.typeArtigo
local.scopus.citations35
local.scopus.eid2-s2.0-27444432249
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=27444432249&origin=inward
Arquivos
Coleções
Artigos de periódico