Positive tip culture with candida and negative blood culture: To treat or not to treat? A systematic review with meta-analysis

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dc.contributor.authorDe Almeida B.M.
dc.contributor.authorBreda G.L.
dc.contributor.authorQueiroz-Telles F.
dc.contributor.authorTuon F.F.
dc.date.accessioned2024-03-13T00:59:50Z
dc.date.available2024-03-13T00:59:50Z
dc.date.issued2014
dc.description.abstract© 2014 Informa Healthcare.Background: Invasive candidiasis is a major invasive fungal infection. It has high lethality, and even higher if not treated early. There is no consensus on antifungal treatment in patients with positive catheter tip culture for Candida spp. The objective of this study was to evaluate the impact of antifungal therapy and mortality of patients with positive culture for Candida spp. in catheter tip that have negative blood culture. Methods: The PubMed database was searched to identify articles related to Candida and catheter. Articles with adequate data were included. Results: Of 1208 studies initially screened, 5 met the selection criteria. All were retrospective studies. In all, 265 patients were evaluated for outcomes 'candidemia' and 'invasive candidiasis' and 158 for the outcome 'mortality.' Antifungal therapy had no impact on the development of invasive fungal disease (Odds ratio (OR) = 1.41; 95% confidence interval (CI) = 0.56-3.52). Also there was no benefit of therapy on mortality (OR = 1.02; 95% CI = 0.54-1.95). Conclusion: Due to the poor quality of the studies no conclusion can be made. Randomized prospective studies are needed to better evaluate this therapeutic strategy.
dc.description.firstpage854
dc.description.issuenumber12
dc.description.lastpage861
dc.description.volume46
dc.identifier.doi10.3109/00365548.2014.952246
dc.identifier.issn1651-1980
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/36347
dc.relation.ispartofScandinavian Journal of Infectious Diseases
dc.rightsAcesso Restrito
dc.titlePositive tip culture with candida and negative blood culture: To treat or not to treat? A systematic review with meta-analysis
dc.typeArtigo de revisão
local.scopus.citations5
local.scopus.eid2-s2.0-84911373297
local.scopus.subjectAntifungal Agents
local.scopus.subjectCandida
local.scopus.subjectCandidemia
local.scopus.subjectCandidiasis
local.scopus.subjectCatheters
local.scopus.subjectHumans
local.scopus.subjectOdds Ratio
local.scopus.subjectRetrospective Studies
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84911373297&origin=inward
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