Mortality rate in patients with nosocomial acinetobacter meningitis from a Brazilian hospital

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dc.contributor.authorTuon F.F.
dc.contributor.authorPenteado-Filho S.R.
dc.contributor.authorAmarante D.
dc.contributor.authorAndrade M.A.
dc.contributor.authorBorba L.A.
dc.date.accessioned2024-03-13T01:32:21Z
dc.date.available2024-03-13T01:32:21Z
dc.date.issued2010
dc.description.abstractBackground: The mortality rate due to Acinetobacter baumannii nosocomial meningitis (ANM) is high. Objective: The aim of this study was to evaluate the factors that have infl uence over the outcomes in ANM patients. Methods: A retrospective analysis of 22 cases of ANM was conducted in a hospital with high incidence of multidrug resistance. Results: The mean age of patients was 43 years (21 to 91) and 54.5% were male. All ANM cases occurred within 60 days of admission and the mean duration of illness was of 18.2 days. All cases were associated with previous neurosurgical procedures: elective surgery (27.2%), external shunt (54.4%) and emergency surgery due to trauma (18.1%). Imipenem resistance was observed in 40.9% of cases, but ampicillin/sulbactam resistance was lower (27.2%). The mortality rate of ANM patients was of 72.7%. The only risk factor associated with mortality was inappropriate therapy within fi ve days after CSF collection. All patients who survived the meningitis episode had received appropriate therapy, in contrast to only 69.2% of those who did not survive (OR = 5.15; IC = 0.45-54.01). Conclusions: The high mortality rate observed in our study suggests the need for aggressive empirical treatment with addition of drugs, including intrathecal therapy, where multi-resistant A. baumannii is endemic. © Elsevier Editora Ltda.
dc.description.firstpage437
dc.description.issuenumber5
dc.description.lastpage440
dc.description.volume14
dc.identifier.doi10.1590/S1413-86702010000500003
dc.identifier.issn1413-8670
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/37230
dc.relation.ispartofBrazilian Journal of Infectious Diseases
dc.rightsAcesso Aberto
dc.subject.otherlanguageAcinetobacter
dc.subject.otherlanguageAcinetobacter baumannii
dc.subject.otherlanguageAmpicillin/sulbactam
dc.subject.otherlanguageImipenem
dc.subject.otherlanguageMeningitis
dc.subject.otherlanguageNeurosurgery
dc.titleMortality rate in patients with nosocomial acinetobacter meningitis from a Brazilian hospital
dc.typeArtigo
local.scopus.citations51
local.scopus.eid2-s2.0-78951476419
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=78951476419&origin=inward
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