Superficial papillary urothelial neoplasms of the bladder (pTa e pT1): Correlation of expression of p53, KI-67 and CK20 with histologic grade, recurrence and tumor progression Neoplasias uroteliais papilíferas superficiais da bexiga (pTa e pT1): Correlação da expressão do p53, KI-67 E CK20 com grau histológico, recidiva e progressão tumoral

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dc.contributor.authorOgata D.C.
dc.contributor.authorMarcondes C.A.P.R.
dc.contributor.authorTuon F.F.
dc.contributor.authorBusato Junior W.F.S.
dc.contributor.authorCavalli G.
dc.contributor.authorCzeczko L.E.A.
dc.date.accessioned2024-03-13T01:07:22Z
dc.date.available2024-03-13T01:07:22Z
dc.date.issued2012
dc.description.abstractObjective: To investigate the immunohistochemical expressions of p53, ki67, CK20 in superficial papillary urothelial neoplasms of the bladder and correlate them with histological grade, tumor progression and recurrence. Methods: We selected samples of 43 patients with superficial transitional cell carcinoma of the bladder. They were divided into two groups, one called Recurrent (R), with 18 individuals, and other Non-Recurrent (NR), with 25. Multi-sampling blocks were prepared. The immunohistochemical technique employed was immunoperoxidase, and the antibodies were: p53: Novocastra (clone DO7) at a dilution of 1/100; Ki67: Spring (clone SP6) at a dilution of 1/100; and CK20: Dako (clone K20.8) at a dilution of 1/50. Results: The expression of p53 was observed in 11 cases, six in the Recurrent group and five in the Non-Recurrent, all high-grade tumors (p = 0.0001). The histological progression occurred in six patients (p = 0.0076). Of the 18 Recurrent cases, six showed immunoreactivity for p53 and 12 were negative for this antibody (p = 0.1715). Ki67 was positive in 17 of the 18 cases from the Recurrent group (p = 0.0001) and, from 20 high-grade tumors, 18 showed reaction to this antibody (p = 0.0001). Of the 18 individuals who had recurrence, 13 showed anomalous expression for CK20 (p = 0.0166). In high-grade carcinomas, of the 20 cases, 16 showed anomalous expression for this antibody, while 18 of the 23 patients with low-grade tumors showed normal expression for CK20 (p = 0.0002). Conclusion: The p53 showed good correlation with histological progression and histologic grade. Ki67 was strongly associated with recurrence and histological grade, and CK20 was also associated with these variables.
dc.description.firstpage394
dc.description.issuenumber5
dc.description.lastpage400
dc.description.volume39
dc.identifier.doi10.1590/S0100-69912012000500010
dc.identifier.issn0100-6991
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/36768
dc.relation.ispartofRevista do Colegio Brasileiro de Cirurgioes
dc.rightsAcesso Aberto
dc.subject.otherlanguageBiological makers
dc.subject.otherlanguageImmunohistochemistry
dc.subject.otherlanguageNeoplasms
dc.subject.otherlanguageUrinary bladder
dc.subject.otherlanguageUrinary bladder neoplasms
dc.titleSuperficial papillary urothelial neoplasms of the bladder (pTa e pT1): Correlation of expression of p53, KI-67 and CK20 with histologic grade, recurrence and tumor progression Neoplasias uroteliais papilíferas superficiais da bexiga (pTa e pT1): Correlação da expressão do p53, KI-67 E CK20 com grau histológico, recidiva e progressão tumoral
dc.typeArtigo
local.scopus.citations13
local.scopus.eid2-s2.0-84870586367
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84870586367&origin=inward
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