Prevalence of thyroid autoantibodies in patients with systematic autoimmune rheumatic diseases. Cross-sectional study

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dc.contributor.authorPosselt R.T.
dc.contributor.authorCoelho V.N.
dc.contributor.authorPigozzo D.C.
dc.contributor.authorGuerrer M.I.
dc.contributor.authorFagundes M.C.
dc.contributor.authorNisihara R.
dc.contributor.authorSkare T.L.
dc.date.accessioned2024-03-13T00:48:09Z
dc.date.available2024-03-13T00:48:09Z
dc.date.issued2017
dc.description.abstract© 2017, Associacao Paulista de Medicina. All rights reserved.BACKGROUND: Thyroid autoimmunity is more common in patients with rheumatic diseases than in healthy populations. The degree of association seems subject to influence from patients’ geographical location. Here, we aimed to ascertain the prevalence of thyroid autoantibodies in a cohort of patients with systemic rheumatic disease and the degree of association between its presence and inflammatory activity. DESIGN AND SETTING: Cross-sectional observational study in a rheumatology unit. METHODS: 301 patients with systemic lupus erythematosus (SLE), 210 with rheumatoid arthritis (RA), 58 with scleroderma (SSc) and 80 with spondyloarthritis (SpA) were studied regarding thyroid function (TSH and T4), anti-thyroglobulin (TgAb) and anti-thyroperoxidase (TPOab) and compared with 141 healthy controls. Disease activity in patients with rheumatic disease was assessed through appropriate indexes. RESULTS: There were more antithyroid antibodies in SLE patients with hypothyroidism (P = 0.01; odds ratio, OR 2.7; 95% confidence interval, CI: 1.20-6.26) and in those without hypothyroidism (P = 0.06; OR 2.4; 95% CI: 1.28-4.55) than in controls. SSc patients also showed P = 0.03 both with antithyroid antibodies and hypothyroidism (OR 3.4; 95% CI: 1.06-10.80) and without hypothyroidism (OR 3.1; 95% CI: 1.11-0.13). RA and SpA patients had the same prevalence as controls (P not significant). Presence of autoantibodies with and without hypothyroidism was not associated with the activity or functional indexes evaluated. CONCLUSION: SLE and SSc were associated with higher prevalence of thyroid autoantibodies in patients with and without hypothyroidism, unlike SpA and RA. There was no link between thyroid autoantibody presence and disease activity or functional impairment.
dc.description.firstpage535
dc.description.issuenumber6
dc.description.lastpage540
dc.description.volume135
dc.identifier.doi10.1590/1516-3180.2017.0089110617
dc.identifier.issn1516-3180
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/35697
dc.relation.ispartofSao Paulo Medical Journal
dc.rightsAcesso Aberto
dc.subject.otherlanguageAutoimmunity
dc.subject.otherlanguageRheumatic disease
dc.subject.otherlanguageThyroid
dc.titlePrevalence of thyroid autoantibodies in patients with systematic autoimmune rheumatic diseases. Cross-sectional study
dc.typeArtigo
local.scopus.citations9
local.scopus.eid2-s2.0-85038445758
local.scopus.subjectAdult
local.scopus.subjectArthritis, Rheumatoid
local.scopus.subjectAutoantibodies
local.scopus.subjectAutoimmune Diseases
local.scopus.subjectCase-Control Studies
local.scopus.subjectCross-Sectional Studies
local.scopus.subjectDisability Evaluation
local.scopus.subjectFemale
local.scopus.subjectHumans
local.scopus.subjectIodide Peroxidase
local.scopus.subjectLupus Erythematosus, Systemic
local.scopus.subjectMale
local.scopus.subjectMiddle Aged
local.scopus.subjectPrevalence
local.scopus.subjectRheumatic Diseases
local.scopus.subjectScleroderma, Systemic
local.scopus.subjectSpondylarthropathies
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85038445758&origin=inward
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