Bifrontal tDCS prevents implicit learning acquisition in antidepressant-free patients with major depressive disorder

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dc.contributor.authorBrunoni A.R.
dc.contributor.authorZanao T.A.
dc.contributor.authorFerrucci R.
dc.contributor.authorPriori A.
dc.contributor.authorValiengo L.
dc.contributor.authorde Oliveira J.F.
dc.contributor.authorBoggio P.S.
dc.contributor.authorLotufo P.A.
dc.contributor.authorBensenor I.M.
dc.contributor.authorFregni F.
dc.date.accessioned2024-03-13T01:04:30Z
dc.date.available2024-03-13T01:04:30Z
dc.date.issued2013
dc.description.abstractThe findings for implicit (procedural) learning impairment in major depression are mixed. We investigated this issue using transcranial direct current stimulation (tDCS), a method that non-invasively increases/decreases cortical activity. Twenty-eight age- and gender-matched, antidepressant-free depressed subjects received a single-session of active/sham tDCS. We used a bifrontal setup - anode and cathode over the left and the right dorsolateral prefrontal cortex (DLPFC), respectively. The probabilistic classification-learning (PCL) task was administered before and during tDCS. The percentage of correct responses improved during sham; although not during active tDCS. Procedural or implicit learning acquisition between tasks also occurred only for sham. We discuss whether DLPFC activation decreased activity in subcortical structures due to the depressive state. The deactivation of the right DLPFC by cathodal tDCS can also account for our results. To conclude, active bifrontal tDCS prevented implicit learning in depressive patients. Further studies with different tDCS montages and in other samples are necessary. © 2012 Elsevier Inc.
dc.description.firstpage146
dc.description.lastpage150
dc.description.volume43
dc.identifier.doi10.1016/j.pnpbp.2012.12.019
dc.identifier.issn0278-5846
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/36607
dc.relation.ispartofProgress in Neuro-Psychopharmacology and Biological Psychiatry
dc.rightsAcesso Aberto
dc.subject.otherlanguageImplicit memory
dc.subject.otherlanguageMajor depressive disorder
dc.subject.otherlanguageProbabilistic classification learning
dc.subject.otherlanguageProcedural learning
dc.subject.otherlanguageTranscranial direct current stimulation
dc.titleBifrontal tDCS prevents implicit learning acquisition in antidepressant-free patients with major depressive disorder
dc.typeArtigo
local.scopus.citations28
local.scopus.eid2-s2.0-84872507236
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84872507236&origin=inward
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