Thyroid hormone receptor β-specific agonist GC-1 increases energy expenditure and prevents fat-mass accumulation in rats

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dc.contributor.authorVillicev C.M.
dc.contributor.authorFreitas F.R.S.
dc.contributor.authorAoki M.S.
dc.contributor.authorTaffarel C.
dc.contributor.authorScanlan T.S.
dc.contributor.authorMoriscot A.S.
dc.contributor.authorRibeiro M.O.
dc.contributor.authorBianco A.C.
dc.contributor.authorGouveia C.H.A.
dc.date.accessioned2024-03-13T01:40:00Z
dc.date.available2024-03-13T01:40:00Z
dc.date.issued2007
dc.description.abstractIt is well known that thyroid hormone affects body composition; however, the effect of the thyroid hormone receptor β (TRβ)-selective thyromimetic GC-1 on this biological feature had not been demonstrated. In the current study, we compared the effects of a 6-week treatment with triiodothyronine (T3; daily injections of 3 or 6 μg/100 g body weight) or GC-1 (equimolar doses) on different metabolic parameters in adult female rats. Whereas all animals gained weight (17-25 g) in a way not basically affected by T3 or GC-1 treatment, only T3 treatment selectively increased food intake (50-70%). Oxygen consumption was significantly and equally increased (50-70%) by T3 and GC-1. Analysis of body composition by dual-energy X-ray absorptiometry (DEXA) revealed that, whereas control animals gained about 80% of fat mass, T3- or GC-1-treated animals lost 70-90 and ∼20% respectively. Direct analysis of the carcass showed that T3 treatment promoted a 14-74% decrease in fat content but GC-1 treatment promoted only a 15-23% reduction. The gain in lean mass by DEXA and the carcass protein content were not affected by T3 or GC-1 treatment. However, the mass of individual skeletal muscles was negatively affected by T3 but only barely by GC-1. These findings highlight the potential use of GC-1 for the treatment of obesity and the metabolic syndrome. © 2007 Society for Endocrinology.
dc.description.firstpage21
dc.description.issuenumber1
dc.description.lastpage29
dc.description.volume193
dc.identifier.doi10.1677/joe.1.07066
dc.identifier.issn0022-0795
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/37655
dc.relation.ispartofJournal of Endocrinology
dc.rightsAcesso Aberto
dc.titleThyroid hormone receptor β-specific agonist GC-1 increases energy expenditure and prevents fat-mass accumulation in rats
dc.typeArtigo
local.scopus.citations95
local.scopus.eid2-s2.0-34247344167
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=34247344167&origin=inward
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