Lipid profile in adult patients with idiopathic juvenile arthritis

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dc.contributor.authorSkare T.L.
dc.contributor.authorSilva M.B.
dc.contributor.authorNegreiros P.
dc.date.accessioned2024-03-13T01:05:56Z
dc.date.available2024-03-13T01:05:56Z
dc.date.issued2013
dc.description.abstractThe inflammatory processes in the joints of a child with juvenile idiopathic arthritis (JIA) can persist into adulthood. Inflammation has been linked to distortions of the lipid profile and accelerated atherogenesis. In the present study, we examined the lipid profi les of adults with JIA compared with those of healthy people. A lipid profi le of a sample of 54 adults with JIA (57.3% with polyarticular JIA, 37.0% with oligoarticular JIA, 1.9% with enthesitis-related JIA and 3.7% with systemic onset JIA) and 54 healthy subjects were compared. In the adults with JIA, data on gender, age, age at disease onset, the presence of rheumatoid factor (RF) and antinuclear antibodies (ANA), a Health Assessment Questionnaire (HAQ) and the disease duration were collected. We found that hypercholesterolaemia, increased low-density lipoprotein (LDL) and decreased high-density lipoprotein (HDL) were more common in patients with JIA than the controls (P = 0.016, P < 0.0001 and P = 0.0008, respectively). Changes in the levels of total cholesterol (TC) and LDL were more common in the individuals who had a later onset of disease (P = 0.0017 for TC and P = 0.023 for LDL). In the entire JIA group, no other variable, such as RF, ANA, disease duration or responses to the HAQ, could be linked to dyslipidaemia (P = non-signifi cant). We concluded that the adult patients with JIA have a lipid profi le with increased TC and LDL levels and decreased levels of HDL compared to the controls. No clinical feature could be correlated with this change except for the age at disease onset. © 2013 Elsevier Editora Ltda.
dc.description.firstpage371
dc.description.issuenumber4
dc.description.lastpage374
dc.description.volume53
dc.identifier.doi10.1590/S0482-50042013000400011
dc.identifier.issn0482-5004
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/36687
dc.relation.ispartofRevista Brasileira de Reumatologia
dc.rightsAcesso Aberto
dc.subject.otherlanguageDyslipidaemias cholesterol
dc.subject.otherlanguageHDL cholesterol
dc.subject.otherlanguageJuvenile rheumatoid
dc.subject.otherlanguageLDL triglycerides arthritis
dc.titleLipid profile in adult patients with idiopathic juvenile arthritis
dc.typeArtigo
local.scopus.citations4
local.scopus.eid2-s2.0-84889636386
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84889636386&origin=inward
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