Omega-3 fatty acid supplementation reduces resting heart rate of rats with epilepsy

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dc.contributor.authorLopes M.D.
dc.contributor.authorColugnati D.B.
dc.contributor.authorLopes A.C.
dc.contributor.authorScorza C.A.
dc.contributor.authorCavalheiro E.A.
dc.contributor.authorCysneiros R.M.
dc.contributor.authorScorza F.A.
dc.date.accessioned2024-03-13T01:04:33Z
dc.date.available2024-03-13T01:04:33Z
dc.date.issued2013
dc.description.abstractSince cardiovascular dysfunction may contribute to sudden unexpected death in epilepsy (SUDEP), the consumption of omega-3 fatty acids (omega-3 FAs) might be beneficial as an adjunctive therapy for SUDEP prevention. It is well recognized that omega-3 FAs exert positive effects on the cardiovascular system including heart rate (HR) reduction, a major risk factor to sudden death. Thus, we evaluated the effects of chronic supplementation of omega-3 FAs on the HR of rats with epilepsy. In agreement with our previous investigations, this study also showed that the HR of animals with epilepsy is higher than that of the control group. Quite interestingly, chronic supplementation with omega-3 FAs restored the HR of rats with epilepsy toward control values. In conclusion, although further investigations are still required, our preliminary results showed a potential preventive effect of omega-3 FA supplementation against SUDEP. © 2013 Elsevier Inc.
dc.description.firstpage504
dc.description.issuenumber3
dc.description.lastpage506
dc.description.volume27
dc.identifier.doi10.1016/j.yebeh.2013.02.017
dc.identifier.issn1525-5050
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/36610
dc.relation.ispartofEpilepsy and Behavior
dc.rightsAcesso Restrito
dc.subject.otherlanguageEpilepsy
dc.subject.otherlanguageHeart rate
dc.subject.otherlanguageOmega-3 fatty acids (omega-3 FAs)
dc.subject.otherlanguagePilocarpine
dc.subject.otherlanguageSUDEP
dc.titleOmega-3 fatty acid supplementation reduces resting heart rate of rats with epilepsy
dc.typeArtigo
local.scopus.citations5
local.scopus.eid2-s2.0-84877357214
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84877357214&origin=inward
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