Effects of exposure to glyphosate in male and female mice behavior in pubertal period Efeitos comportamentais da exposição na puberdade de camundongos machos e fêmeas ao glifosato

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dc.contributor.authorJoaquim A.O.
dc.contributor.authorMacrini D.J.
dc.contributor.authorRicci E.L.
dc.contributor.authorRodrigues P.A.
dc.contributor.authorSpinosa H.S.
dc.contributor.authorSuffredini I.B.
dc.contributor.authorBernardi M.M.
dc.date.accessioned2024-03-13T01:01:35Z
dc.date.available2024-03-13T01:01:35Z
dc.date.issued2014
dc.description.abstract© 2014, Universidade de Sao Paulo. Faculdade de Medicina Veterinaria e Zootecnia, All rights reserved.The present study aims to investigate the effects of pre-pubertal exposure of male and female mice to a commercial formulation of glyphosate on sexual dimorphism observed in animal models of emotionality, anxiety and depression. For this, mice were exposed from 23 days of age (PND) until PND 45 to glyphosate (50 mg/kg, per os) or saline solution, and, ten days after the end of treatments, male and female mice were observed in the open field (OF), elevated plus maze (EPM) or forced swimming test (FWT). Results showed that exposure to glyphosate: 1) reduced the locomotion frequency of male mice similarly to female mice in the OF and female mice had an increase in rearing behavior and in the immobility time; 2) reduced in male mice the motor activity both in the OF and EPM, while no effects were observed in female mice; 3) in the SWT male mice had a decreased time of float similarly female mice. We concluded that pre-pubertal exposure to glyphosate reduced in male mice the capacity of exploration in the OF and EPM tests suggesting that the herbicide interfered with the central mechanism related to brain masculinization of exploratory and anxiety behavioral models. In the FWT it was observed a decreased depressive response in male mice while in female an increased response was detected.
dc.description.firstpage194
dc.description.issuenumber3
dc.description.lastpage203
dc.description.volume51
dc.identifier.doi10.11606/issn.1678-4456.v51i3p194-203
dc.identifier.issn1678-4456
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/36443
dc.relation.ispartofBrazilian Journal of Veterinary Research and Animal Science
dc.rightsAcesso Aberto
dc.subject.otherlanguageAnimal behavior
dc.subject.otherlanguageAnxiety
dc.subject.otherlanguageDepression
dc.subject.otherlanguageExploration
dc.subject.otherlanguageHerbicide
dc.subject.otherlanguageSex differences
dc.titleEffects of exposure to glyphosate in male and female mice behavior in pubertal period Efeitos comportamentais da exposição na puberdade de camundongos machos e fêmeas ao glifosato
dc.typeArtigo
local.scopus.citations3
local.scopus.eid2-s2.0-84920279179
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84920279179&origin=inward
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