Evaluation of carotid artery intima-media complex thickness as a marker of vascular damage secondary to accelerated atherogenesis in progressive systemic sclerosis Avaliação da espessura do complexo médio-intimal da artéria carótida como marcador de aterogênese acelerada secundária a dano vascular na esclerose sistêmica progressiva

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dc.contributor.authorMacedo R.
dc.contributor.authorAndretta M.
dc.contributor.authorAlbers C.
dc.contributor.authorSkare T.
dc.contributor.authorRibas-Filho J.M.
dc.contributor.authorCzeczko N.G.
dc.date.accessioned2024-03-13T01:09:24Z
dc.date.available2024-03-13T01:09:24Z
dc.date.issued2012
dc.description.abstractObjective: To evaluate the intima-media thickness of the common carotid artery in patients with and without scleroderma; to verify a possible association with disease severity; to assess the relationship of intima-media thickness with known cardiovascular risk factors. Methods: In a case-control study, were selected 30 patients with scleroderma and 30 without the disease and matched according to age, sex and cardiovascular risk factors such as hypertension, diabetes mellitus and hypercholesterolemia. The age ranged from 17 to 79 years (mean 49). All patients underwent carotid artery evaluation by high-resolution vascular Doppler in order to measure the intima-medial thickness of the carotid 2 cm from the bifurcation. In all the analysis was considered the greatest value of intima-media thickness in right and left carotid arteries. Results: The sample consisted of 30 patients, being 29 (96.67%) women and one man (3.3%). In this sample, 11/30 (36.67%) had high blood pressure, 5/30 (16.67%) had diabetes mellitus, 6/30 (20%) had dyslipidemia and 2/30 (6.67%) were smokers. Comparing the measure of the increased risk (maximum intima-media thickness between the left and right side), was obtained an average of 0.77 mm for group scleroderma and a value of 0.70 mm for the control group (p = 0.21). In assessing the association between disease severity and carotid intima-media thickness, was found no significant association (p= 0.925). Conclusion: Was found a slight increase in intima-medial thickness of common carotid artery in patients with scleroderma but without statistical significance. Regarding the severity of the disease and intimamedial thickness of common carotid artery, there was no significant difference.
dc.description.firstpage10
dc.description.issuenumber1
dc.description.lastpage15
dc.description.volume39
dc.identifier.doi10.1590/s0100-69912012000100004
dc.identifier.issn1809-4546
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/36883
dc.relation.ispartofRevista do Colegio Brasileiro de Cirurgioes
dc.rightsAcesso Aberto
dc.subject.otherlanguageAtherosclerosis
dc.subject.otherlanguageCarotid arteries
dc.subject.otherlanguageCarotid intima-media thickness
dc.subject.otherlanguagePatients
dc.subject.otherlanguageScleroderma
dc.subject.otherlanguageSystemic
dc.titleEvaluation of carotid artery intima-media complex thickness as a marker of vascular damage secondary to accelerated atherogenesis in progressive systemic sclerosis Avaliação da espessura do complexo médio-intimal da artéria carótida como marcador de aterogênese acelerada secundária a dano vascular na esclerose sistêmica progressiva
dc.typeArtigo
local.scopus.citations6
local.scopus.eid2-s2.0-84859555838
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84859555838&origin=inward
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