Induction of type 2 iodothyronine deiodinase after status epilepticus modifies hippocampal gene expression in male mice

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dc.contributor.authorNascimento B.P.P.
dc.contributor.authorBocco B.M.L.C.
dc.contributor.authorFernandes G.W.
dc.contributor.authorFonseca T.L.
dc.contributor.authorMcAninch E.A.
dc.contributor.authorCardoso C.V.
dc.contributor.authorBondan E.F.
dc.contributor.authorNassif R.J.
dc.contributor.authorCysneiros R.M.
dc.contributor.authorBianco A.C.
dc.contributor.authorRibeiro M.O.
dc.date.accessioned2024-03-12T23:57:18Z
dc.date.available2024-03-12T23:57:18Z
dc.date.issued2018
dc.description.abstractCopyright © 2018 Endocrine SocietyStatus epilepticus (SE) is an abnormally prolonged seizure that results from either a failure of mechanisms that terminate seizures or from initiating mechanisms that inherently lead to prolonged seizures. Here we report that mice experiencing a 3 hours of SE caused by pilocarpine exhibit a rapid increase in expression of type 2 iodothyronine deiodinase gene (Dio2) and a decrease in the expression of type 3 iodothyronine deiodinase gene in hippocampus, amygdala and prefrontal cortex. Type 3 iodothyronine deiodinase in hippocampal sections was seen concentrated in the neuronal nuclei, typical of ischemic injury of the brain. An unbiased analysis of the hippocampal transcriptome of mice undergoing 3 hours of SE revealed a number of genes, including those involved with response to oxidative stress, cellular homeostasis, cell signaling, and mitochondrial structure. In contrast, in mice with targeted disruption of Dio2 in astrocytes (Astro D2KO mouse), the highly induced genes in the hippocampus were related to inflammation, apoptosis, and cell death. We propose that Dio2 induction caused by SE accelerates production of T3 in different areas of the central nervous system and modifies the hippocampal gene expression profile, affecting the balance between adaptive and maladaptive mechanisms.
dc.description.firstpage3090
dc.description.issuenumber8
dc.description.lastpage3104
dc.description.volume159
dc.identifier.doi10.1210/en.2018-00146
dc.identifier.issn1945-7170
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/35498
dc.relation.ispartofEndocrinology
dc.rightsAcesso Aberto
dc.titleInduction of type 2 iodothyronine deiodinase after status epilepticus modifies hippocampal gene expression in male mice
dc.typeArtigo
local.scopus.citations7
local.scopus.eid2-s2.0-85055855790
local.scopus.subjectAmygdala
local.scopus.subjectAnimals
local.scopus.subjectApoptosis
local.scopus.subjectAstrocytes
local.scopus.subjectCell Death
local.scopus.subjectCell Nucleus
local.scopus.subjectGene Expression
local.scopus.subjectHippocampus
local.scopus.subjectInflammation
local.scopus.subjectIodide Peroxidase
local.scopus.subjectMale
local.scopus.subjectMice
local.scopus.subjectMice, Knockout
local.scopus.subjectMuscarinic Agonists
local.scopus.subjectNeurons
local.scopus.subjectOxidative Stress
local.scopus.subjectPilocarpine
local.scopus.subjectPrefrontal Cortex
local.scopus.subjectSignal Transduction
local.scopus.subjectStatus Epilepticus
local.scopus.subjectTriiodothyronine
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85055855790&origin=inward
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