Bladder carcinoma data with clinical risk factors and molecular markers: A cluster analysis

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dc.contributor.authorRedondo-Gonzalez E.
dc.contributor.authorDe Castro L.N.
dc.contributor.authorMoreno-Sierra J.
dc.contributor.authorMaestro De Las Casas M.L.
dc.contributor.authorVera-Gonzalez V.
dc.contributor.authorFerrari D.G.
dc.contributor.authorCorchado J.M.
dc.date.accessioned2024-03-13T00:59:29Z
dc.date.available2024-03-13T00:59:29Z
dc.date.issued2015
dc.description.abstract© 2015 Enrique Redondo-Gonzalez et al.Bladder cancer occurs in the epithelial lining of the urinary bladder and is amongst the most common types of cancer in humans, killing thousands of people a year. This paper is based on the hypothesis that the use of clinical and histopathological data together with information about the concentration of various molecular markers in patients is useful for the prediction of outcomes and the design of treatments of nonmuscle invasive bladder carcinoma (NMIBC). A population of 45 patients with a new diagnosis of NMIBC was selected. Patients with benign prostatic hyperplasia (BPH), muscle invasive bladder carcinoma (MIBC), carcinoma in situ (CIS), and NMIBC recurrent tumors were not included due to their different clinical behavior. Clinical history was obtained by means of anamnesis and physical examination, and preoperative imaging and urine cytology were carried out for all patients. Then, patients underwent conventional transurethral resection (TURBT) and some proteomic analyses quantified the biomarkers (p53, neu, and EGFR). A postoperative follow-up was performed to detect relapse and progression. Clusterings were performed to find groups with clinical, molecular markers, histopathological prognostic factors, and statistics about recurrence, progression, and overall survival of patients with NMIBC. Four groups were found according to tumor sizes, risk of relapse or progression, and biological behavior. Outlier patients were also detected and categorized according to their clinical characters and biological behavior.
dc.description.volume2015
dc.identifier.doi10.1155/2015/168682
dc.identifier.issn2314-6141
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/36327
dc.relation.ispartofBioMed Research International
dc.rightsAcesso Aberto
dc.titleBladder carcinoma data with clinical risk factors and molecular markers: A cluster analysis
dc.typeArtigo
local.scopus.citations42
local.scopus.eid2-s2.0-84926442223
local.scopus.subjectBiomarkers, Tumor
local.scopus.subjectDatabases, Factual
local.scopus.subjectDisease-Free Survival
local.scopus.subjectFemale
local.scopus.subjectHumans
local.scopus.subjectMale
local.scopus.subjectNeoplasm Proteins
local.scopus.subjectRisk Factors
local.scopus.subjectSurvival Rate
local.scopus.subjectUrinary Bladder Neoplasms
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84926442223&origin=inward
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