Synthesis of poly(N-vinyl pyrrolidone) (PVP) nanogels by gamma irradiation using different saturation atmospheres

dc.contributor.authorBalogh T.S.
dc.contributor.authorBonturim E.
dc.contributor.authorVieira L.D.
dc.contributor.authorLugao A.B.
dc.contributor.authorKadlubowski S.
dc.date.accessioned2024-03-12T19:14:11Z
dc.date.available2024-03-12T19:14:11Z
dc.date.issued2022
dc.description.abstract© 2022 Elsevier LtdNanogels are internally crosslinked particles of nanometric size used in various fields e.g. as such as carriers in drug delivery systems. They can be produced using ionizing radiation in dilute aqueous solutions. This method is carried out in a pure polymer-solvent system, avoiding the addition of any additives such as monomers, surfactants, catalysts and crosslinking agents and no further purification step is necessary. Poly(N-vinyl pyrrolidone) (PVP K-90) nanogels were prepared by gamma irradiation in an aqueous solution. The samples were prepared in triplicate in multipurpose cobalt-60 gamma irradiator using 1, 10, 25 and 100 mM PVP solutions. Samples were irradiated in argon and nitrous oxide conditions with doses from 1 kGy up to 25 kGy with 10 kGy/h dose rate. The mean particle size (Rh) was determined by Dynamic Light Scattering (DLS) and radius of gyration (Rg) and weight-average molecular weight (Mw) by Static Light Scattering (SLS). These samples were morphologically characterized using Atomic Force Microscopy (AFM) and Transmission Electron Microscopy (TEM). Samples prepared with 100 mM PVP K-90 solution formed macroscopic gels, in the samples obtained with 25 mM PVP K-90 solution there was a prevalence of intermolecular crosslinking. On the other hand, in the samples generated with 10 mM PVP K-90 solution, there was a predominance of intramolecular crosslinking demonstrated in the tendency to: decrease in the radius of gyration (Rg), in the constancy of the weight-average molecular weight (Mw), in the increase in polymer coil density (ρcoil), in the Rg/Rh ratio (shape factor) around 1.0 indicating homogenous, internally cross-linked spheres, in the high relief spherical structures observed in the AFM images and in the spherical particles with high contrast observed in the TEM images. The saturation of the samples with nitrous oxide doubled formation of hydroxyl radicals, favoring the generation of polymeric radicals. Higher average number of radicals in each macromolecule contributed to the higher number of intramolecular crosslinks.
dc.description.volume198
dc.identifier.doi10.1016/j.radphyschem.2022.110238
dc.identifier.issn1879-0895
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/34320
dc.relation.ispartofRadiation Physics and Chemistry
dc.rightsAcesso Restrito
dc.subject.otherlanguageArgon
dc.subject.otherlanguageGamma irradiation
dc.subject.otherlanguageIntramolecular crosslinking
dc.subject.otherlanguageNanogel
dc.subject.otherlanguageNitrous oxide
dc.subject.otherlanguagepoly(N-vinyl pyrrolidone)
dc.titleSynthesis of poly(N-vinyl pyrrolidone) (PVP) nanogels by gamma irradiation using different saturation atmospheres
dc.typeArtigo
local.scopus.citations1
local.scopus.eid2-s2.0-85130536037
local.scopus.subjectAtomic-force-microscopy
local.scopus.subjectCrosslinked
local.scopus.subjectGamma irradiation
local.scopus.subjectIntramolecular crosslinking
local.scopus.subjectN-vinyl pyrrolidone
local.scopus.subjectNanogels
local.scopus.subjectNitrous oxide
local.scopus.subjectPoly(N-vinyl pyrrolidone)
local.scopus.subjectRadius of gyration
local.scopus.subjectWeight-average molecular weight
local.scopus.updated2024-12-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85130536037&origin=inward
Arquivos