Physiological adaptation after a 12-week physical activity program for patients with Prader-Willi syndrome: Two case reports

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dc.contributor.authorAmaro A.S.
dc.contributor.authorTeixeira M.C.T.V.
dc.contributor.authorDe Mesquita M.L.G.
dc.contributor.authorRodrigues G.M.
dc.contributor.authorRubin D.A.
dc.contributor.authorCarreiro L.R.R.
dc.date.accessioned2024-03-13T00:53:00Z
dc.date.available2024-03-13T00:53:00Z
dc.date.issued2016
dc.description.abstract© 2016 The Author(s).Background: Physical activity programs are a powerful tool against several diseases including obesity and their comorbidities. Prader-Willi syndrome is the most common genetic disease associated with obesity, and brings with it behavioral and emotional problems that need complex management. Research into the effect of physical activity programs on Prader-Willi syndrome is limited and it is frequently argued that if a physical activity program is too complex, the participants are more likely to drop out. Therefore, in this study, we assessed the physiological adaptation effect of a physical activity program with increasing complexity and load, in a boy and a girl with Prader-Willi syndrome by assessing changes in lipid profile, body composition, and physical fitness parameters. Case presentation: Case 1 was an 11-year-old girl, mixed race (brown), with an intelligence quotient of 68, 52.0 % body fat, and a body mass index of 45.3 kg/m2. The Prader-Willi syndrome diagnosis was made when she was 5-years old and was found to be due to an imprinting genomic defect. Case 2 was a 14-year-old boy, mixed race (brown), with an intelligence quotient of 74, 48.8 % body fat, and a body mass index of 37.3 kg/m2. The diagnosis was made when he was 10-years old and was found to be caused by gene deletion. Both participants presented physical characteristics and behavior problems typical of Prader-Willi syndrome. Case 2 presented high blood pressure, high cholesterol and sleep apnea and had to use continuous positive airway pressure to sleep. Both participants were assessed for 12 weeks (three times a week) using a physical activity program designed to improve strength and muscle hypertrophy. The work load was progressively adjusted as necessary and new exercises were added to the program. Prior to the program, the participants' parents received instructions about managing problem behavior and advice about nutrition. Conclusions: After physical activity program several health markers assessed by biological tests and parental report had improved in both participants. The participants positively accepted the adaptations made to the physical activity program during the study. More studies are necessary to assess the benefits of physical activity in the Prader-Willi syndrome population.
dc.description.issuenumber1
dc.description.volume10
dc.identifier.doi10.1186/s13256-016-0966-8
dc.identifier.issn1752-1947
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/35961
dc.relation.ispartofJournal of Medical Case Reports
dc.rightsAcesso Aberto
dc.subject.otherlanguagePhysical activity
dc.subject.otherlanguagePhysical fitness and body composition
dc.subject.otherlanguagePrader-Willi syndrome
dc.titlePhysiological adaptation after a 12-week physical activity program for patients with Prader-Willi syndrome: Two case reports
dc.typeArtigo
local.scopus.citations5
local.scopus.eid2-s2.0-84978123636
local.scopus.subjectAdaptation, Physiological
local.scopus.subjectAdolescent
local.scopus.subjectChild
local.scopus.subjectDiet
local.scopus.subjectDirective Counseling
local.scopus.subjectExercise
local.scopus.subjectFemale
local.scopus.subjectHealth Knowledge, Attitudes, Practice
local.scopus.subjectHumans
local.scopus.subjectMale
local.scopus.subjectMotivation
local.scopus.subjectNutritional Status
local.scopus.subjectObesity
local.scopus.subjectPatient Compliance
local.scopus.subjectPrader-Willi Syndrome
local.scopus.subjectProgram Evaluation
local.scopus.subjectSleep Apnea Syndromes
local.scopus.subjectTreatment Outcome
local.scopus.subjectWeight Loss
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84978123636&origin=inward
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