Effects of fish oil supplementation on spatial memory in rats with pilocarpine-induced epilepsy assessed using the Morris Water Maze test

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dc.contributor.authorNejm M.B.
dc.contributor.authorVictorino D.B.
dc.contributor.authorGuimaraes-Marques M.J.
dc.contributor.authorScorza C.A.
dc.contributor.authorFinsterer J.
dc.contributor.authorScorza F.A.
dc.contributor.authorCysneiros R.M.
dc.date.accessioned2024-03-12T19:20:15Z
dc.date.available2024-03-12T19:20:15Z
dc.date.issued2021
dc.description.abstract© 2021 Epileptic Disorders.Objective. Patients with temporal lobe epilepsy (TLE) are at high risk of experiencing cognitive impairment. Such dysfunction is also observed in an animal model of TLE, the rat model of pilocarpine-induced epilepsy. Methods. We investigated the effects of fish oil supplementation on spatial memory in rats with pilocarpine-induced epilepsy using the Morris Water Maze (MWM) test. Results. Although rats with pilocarpine-induced epilepsy treated with fish oil learned the platform location significantly faster by Day 7 of the acquisition phase, spatial memory performance of these rats was unaffected by fish oil supplementation during probe trials. Significance. Our study provides insights into the importance of considering nutraceutical strategies for enhancing cognitive abilities in patients with TLE.
dc.description.firstpage476
dc.description.issuenumber3
dc.description.lastpage484
dc.description.volume23
dc.identifier.doi10.1684/epd.2021.1289
dc.identifier.issn1950-6945
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/34646
dc.relation.ispartofEpileptic Disorders
dc.rightsAcesso Restrito
dc.subject.otherlanguagecognitive impairment
dc.subject.otherlanguagefish oil supplementation
dc.subject.otherlanguageMorris Water Mazer
dc.subject.otherlanguagepilocarpine-induced model of epilepsy
dc.subject.otherlanguagespatial learning and memory
dc.subject.otherlanguagetemporal lobe epilepsy
dc.titleEffects of fish oil supplementation on spatial memory in rats with pilocarpine-induced epilepsy assessed using the Morris Water Maze test
dc.typeArtigo
local.scopus.citations3
local.scopus.eid2-s2.0-85111378928
local.scopus.subjectAnimals
local.scopus.subjectDietary Supplements
local.scopus.subjectEpilepsy
local.scopus.subjectEpilepsy, Temporal Lobe
local.scopus.subjectFish Oils
local.scopus.subjectMorris Water Maze Test
local.scopus.subjectPilocarpine
local.scopus.subjectRats
local.scopus.subjectSpatial Memory
local.scopus.updated2024-12-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85111378928&origin=inward
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