ANTI-Trypanosoma cruzi PHENYLPROPANOIDS ISOLATED FROM Baccharis ligustrina C. DC. (ASTERACEAE) FENILPROPANOIDES COM AÇÃO ANTI-Trypanosoma cruzi ISOLADOS DE Baccharis ligustrina C. DC. (ASTERACEAE)

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dc.contributor.authorSilva M.L.
dc.contributor.authorGimenes L.
dc.contributor.authorRomoff P.
dc.contributor.authorSoares M.G.
dc.contributor.authorCamilo F.F.
dc.contributor.authorde Levatti E.V.C.
dc.contributor.authorTempone A.G.
dc.contributor.authorLago J.H.G.
dc.date.accessioned2024-03-12T19:12:29Z
dc.date.available2024-03-12T19:12:29Z
dc.date.issued2023
dc.description.abstract© 2023 Sociedade Brasileira de Quimica. All rights reserved.In the present work, dried aerial parts of Baccharis ligustrina (Asteraceae) were subjected to microwave assisted extraction (MAE) using aqueous solution of 1-butyl-3-methylimidazolium bromide (BMImBr) and the obtained extract was successively partitioned using hexane and EtOAc. Using reduced amounts of extracts and efficient chromatographic steps, four acyl C6C3 derivatives (n-hexacosyl ferulate, n-hexacosyl, n-octacosyl, and n-triacontyl p-coumarates) were obtained from hexane phase whereas two C6C3 acids (ferulic and p-coumaric) were obtained from EtOAc phase. Isolated phenylpropanoids were evaluated against amastigote forms of parasite Trypanosoma cruzi. As result, it was observed that p-coumaric and ferulic acids were inactives whereas alkyl derivatives displayed EC50 values of 6.5 µmol L-1 (n-octacosyl p-coumarate), 9.3 µmol L-1 (n-triacontyl p-coumarate), 15.7 µmol L-1 (n-hexacosyl p-coumarate), and 32.2 µmol L-1 (n-hexacosyl ferulate). All tested compounds displayed reduced toxicity against NCTC cells (CC50 > 200 mmol L-1).
dc.description.firstpage39
dc.description.issuenumber1
dc.description.lastpage42
dc.description.volume46
dc.identifier.doi10.21577/0100-4042.20170953
dc.identifier.issn1678-7064
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/34231
dc.relation.ispartofQuimica Nova
dc.rightsAcesso Aberto
dc.subject.otherlanguageAsteraceae
dc.subject.otherlanguageBaccharis ligustrina C. DC
dc.subject.otherlanguagephenylpropanoids
dc.subject.otherlanguageTrypanosoma cruzi
dc.titleANTI-Trypanosoma cruzi PHENYLPROPANOIDS ISOLATED FROM Baccharis ligustrina C. DC. (ASTERACEAE) FENILPROPANOIDES COM AÇÃO ANTI-Trypanosoma cruzi ISOLADOS DE Baccharis ligustrina C. DC. (ASTERACEAE)
dc.typeArtigo
local.scopus.citations2
local.scopus.eid2-s2.0-85150431431
local.scopus.updated2024-12-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85150431431&origin=inward
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