Exposure to high-fat diet since post-weaning induces cardiometabolic damage in adult rats

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dc.contributor.authorFiorino P.
dc.contributor.authorAmerico A.L.V.
dc.contributor.authorMuller C.R.
dc.contributor.authorEvangelista F.S.
dc.contributor.authorSantos F.
dc.contributor.authorLeite A.P.O.
dc.contributor.authorFarah V.
dc.date.accessioned2024-03-13T00:52:29Z
dc.date.available2024-03-13T00:52:29Z
dc.date.issued2016
dc.description.abstract© 2016 Elsevier Inc.Aims This study sought to investigate the metabolic, hemodynamic and autonomic responses in adult rats exposed to high-fat diet since post-weaning. Main methods Young male Wistar rats were assigned into groups fed with standard normal diet (3% lipids; ND, n = 8) or high-fat diet (30% lipids; HD, n = 8) during 8 weeks. Body composition, food intake, serum triglycerides, total cholesterol, insulin, leptin and adiponectin concentrations were determined. Hemodynamic and autonomic evaluations were performed. Renin angiotensin system and nitric oxide were also studied by pharmacological blockades. Key findings HD group showed no difference in body weight, total cholesterol, food intake in calories and insulin concentration, but visceral fat pads weight, triglycerides and leptin were higher in HD group. Moreover, HD group decreased adiponectin level, increased 12% of mean arterial pressure (MAP) and 6% of heart rate compared with ND group. Spectral analyses showed an increase in cardiovascular sympathetic modulation in HD compared with ND group. Depressor responses after losartan were higher in HD compared with ND group: − 9 ± 0.7 vs.− 3 ± 1.6 mmHg. Pressor responses after L-NAME were higher in HD compared with ND: 45 ± 8 vs. 32 ± 5 mmHg. Significance High-fat diet consumption during early period of life can increase WAT mass and MAP. These alterations may be mediated by an augment in sympathetic activity associated with higher leptin and lower adiponectin levels. These cardiometabolic damages can lead to the development of hypertension and increase cardiovascular risk in adulthood.
dc.description.firstpage12
dc.description.lastpage17
dc.description.volume160
dc.identifier.doi10.1016/j.lfs.2016.07.001
dc.identifier.issn1879-0631
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/35932
dc.relation.ispartofLife Sciences
dc.rightsAcesso Restrito
dc.subject.otherlanguageAdipokines
dc.subject.otherlanguageArterial pressure
dc.subject.otherlanguageAutonomic dysfunction
dc.subject.otherlanguageHigh-fat diet
dc.subject.otherlanguageObesity
dc.titleExposure to high-fat diet since post-weaning induces cardiometabolic damage in adult rats
dc.typeArtigo
local.scopus.citations12
local.scopus.eid2-s2.0-84979900894
local.scopus.subjectAdiposity
local.scopus.subjectAnimals
local.scopus.subjectCardiovascular System
local.scopus.subjectDiet, High-Fat
local.scopus.subjectMale
local.scopus.subjectMetabolism
local.scopus.subjectRats
local.scopus.subjectRats, Wistar
local.scopus.subjectWeaning
local.scopus.subjectWeight Gain
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84979900894&origin=inward
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