Carbamazepine does not alter the intrinsic cardiac function in rats with epilepsy Carbamazepina não altera o funcionamento cardíaco intrínseco em ratos com epilepsia

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dc.contributor.authorColugnati D.B.
dc.contributor.authorArida R.M.
dc.contributor.authorCysneiros R.M.
dc.contributor.authorTerra V.C.
dc.contributor.authorSonoda E.Y.F.
dc.contributor.authorPansani A.P.
dc.contributor.authorScorza C.A.
dc.contributor.authorCavalheiro E.A.
dc.contributor.authorScorza F.A.
dc.date.accessioned2024-03-13T01:32:47Z
dc.date.available2024-03-13T01:32:47Z
dc.date.issued2010
dc.description.abstractAmong the causes for sudden unexpected death (SUDEP) in epilepsy, the effects of antiepileptic drugs on the heart have been poorly explored. Based on this, the aim of our study was to evaluate the heart rate (in vivo and isolated ex vivo) and ventricular pressure (isolated ex vivo) of rats with and without epilepsy treated with carbamazepine. Four groups of adult, male Wistar rats (200-250 g) were studied: [A] control rats (n=8), received neither pilocarpine nor carbamazepine [B] carbamazepine-treated rats (n=8), received a daily dose of 120 mg/Kg, i.p. of carbamazepine for two weeks; [C] rats with epilepsy that received just saline solution (n=8); [D] rats with epilepsy that received a daily dose of 120 mg/Kg, i.p. of carbamazepine for two weeks (n=8). Our results showed significant increase in heart rate in animals with epilepsy (with and without the use of carbamazepine) when compared to the control groups in vivo. In contrast, we did not find differences during isolated ex vivo experiments comparing animals with and without epilepsy and despite the use of carbamazepine. Our results suggest that, in isolation, carbamazepine may not be a potential risk factor for sudden unexpected death in epilepsy.
dc.description.firstpage573
dc.description.issuenumber4
dc.description.lastpage578
dc.description.volume68
dc.identifier.doi10.1590/s0004-282x2010000400018
dc.identifier.issn1678-4227
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/37254
dc.relation.ispartofArquivos de Neuro-Psiquiatria
dc.rightsAcesso Aberto
dc.subject.otherlanguageAntiepileptic drugs
dc.subject.otherlanguageCarbamazepine
dc.subject.otherlanguageEpilepsy
dc.subject.otherlanguageHeart
dc.subject.otherlanguageSeizure
dc.subject.otherlanguageSUDEP
dc.titleCarbamazepine does not alter the intrinsic cardiac function in rats with epilepsy Carbamazepina não altera o funcionamento cardíaco intrínseco em ratos com epilepsia
dc.typeArtigo
local.scopus.citations3
local.scopus.eid2-s2.0-77957310360
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77957310360&origin=inward
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