Early life seizures in female rats lead to anxiety-related behavior and abnormal social behavior characterized by reduced motivation to novelty and deficit in social discrimination

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dc.contributor.authorCastelhano A.S.S.
dc.contributor.authorRamos F.O.
dc.contributor.authorScorza F.A.
dc.contributor.authorCysneiros R.M.
dc.date.accessioned2024-03-13T00:57:38Z
dc.date.available2024-03-13T00:57:38Z
dc.date.issued2015
dc.description.abstract© 2014, Springer-Verlag Wien.Previously, we demonstrated that male Wistar rats submitted to neonatal status epilepticus showed abnormal social behavior characterized by deficit in social discrimination and enhanced emotionality. Taking into account that early insult can produce different biological manifestations in a gender-dependent manner, we aimed to investigate the social behavior and anxiety-like behavior in female Wistar rats following early life seizures. Neonate female Wistar rats at 9 days postnatal were subject to pilocarpine-induced status epilepticus and the control received saline. Behavioral tests started from 60 days postnatal and were carried out only during the diestrus phase of the reproductive cycle. In sociability test experimental animals exhibited reduced motivation for social encounter and deficit in social discrimination. In open field and the elevated plus maze, experimental animals showed enhanced emotionality with no changes in basal locomotor activity. The results showed that female rats submitted to neonatal status epipepticus showed impaired social behavior, characterized by reduced motivation to novelty and deficit in social discrimination in addition to enhanced emotionality.
dc.description.firstpage349
dc.description.issuenumber3
dc.description.lastpage355
dc.description.volume122
dc.identifier.doi10.1007/s00702-014-1291-2
dc.identifier.issn1435-1463
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/36223
dc.relation.ispartofJournal of Neural Transmission
dc.rightsAcesso Restrito
dc.subject.otherlanguageFemale
dc.subject.otherlanguageGeneral anxiety
dc.subject.otherlanguageNeonatal status epilepticus
dc.subject.otherlanguagePilocarpine
dc.subject.otherlanguageSocial behavior
dc.titleEarly life seizures in female rats lead to anxiety-related behavior and abnormal social behavior characterized by reduced motivation to novelty and deficit in social discrimination
dc.typeArtigo
local.scopus.citations17
local.scopus.eid2-s2.0-84939874738
local.scopus.subjectAge Factors
local.scopus.subjectAnalysis of Variance
local.scopus.subjectAnimals
local.scopus.subjectAnimals, Newborn
local.scopus.subjectAnxiety
local.scopus.subjectExploratory Behavior
local.scopus.subjectFemale
local.scopus.subjectMaze Learning
local.scopus.subjectMotivation
local.scopus.subjectRats
local.scopus.subjectRats, Wistar
local.scopus.subjectSeizures
local.scopus.subjectSocial Behavior Disorders
local.scopus.subjectSocial Discrimination
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84939874738&origin=inward
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