Descriptive study of perineuronal net in enteric nervous system of humans and mice

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dc.contributor.authorda Silva M.D.V.
dc.contributor.authorBacarin C.C.
dc.contributor.authorMachado C.C.A.
dc.contributor.authorFranciosi A.
dc.contributor.authorMendes J.D.D.L.
dc.contributor.authorda SilvaWatanabe P.
dc.contributor.authorMiqueloto C.A.
dc.contributor.authorFattori V.
dc.contributor.authorAlbarracin O.Y.E.
dc.contributor.authorVerri W.A.
dc.contributor.authorAktar R.
dc.contributor.authorPeiris M.
dc.contributor.authorAziz Q.
dc.contributor.authorBlackshaw L.A.
dc.contributor.authorde AlmeidaAraujo E.J.
dc.date.accessioned2024-08-01T06:18:05Z
dc.date.available2024-08-01T06:18:05Z
dc.date.issued2024
dc.description.abstract© 2024 International Society for Neurochemistry.Perineuronal nets (PNN) are highly specialized structures of the extracellular matrix around specific groups of neurons in the central nervous system (CNS). They play functions related to optimizing physiological processes and protection neurons against harmful stimuli. Traditionally, their existence was only described in the CNS. However, there was no description of the presence and composition of PNN in the enteric nervous system (ENS) until now. Thus, our aim was to demonstrate the presence and characterize the components of the PNN in the enteric nervous system. Samples of intestinal tissue from mice and humans were analyzed by RT-PCR and immunofluorescence assays. We used a marker (Wisteria floribunda agglutinin) considered as standard for detecting the presence of PNN in the CNS and antibodies for labeling members of the four main PNN-related protein families in the CNS. Our results demonstrated the presence of components of PNN in the ENS of both species; however its molecular composition is species-specific. (Figure presented.)
dc.identifier.doi10.1111/jnc.16159
dc.identifier.issnNone
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/39056
dc.relation.ispartofJournal of Neurochemistry
dc.rightsAcesso Restrito
dc.subject.otherlanguageextracellular matrix
dc.subject.otherlanguagegut
dc.subject.otherlanguageintestine
dc.subject.otherlanguageneuron
dc.subject.otherlanguageperineuronal net
dc.titleDescriptive study of perineuronal net in enteric nervous system of humans and mice
dc.typeArtigo
local.scopus.citations0
local.scopus.eid2-s2.0-85197677654
local.scopus.updated2024-12-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85197677654&origin=inward
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