Component mechanisms of executive function in schizophrenia and their contribution to functional outcomes

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dc.contributor.authorBerberian A.A.
dc.contributor.authorGadelha A.
dc.contributor.authorDias N.M.
dc.contributor.authorMecca T.P.
dc.contributor.authorComfort W.E.
dc.contributor.authorBressan R.A.
dc.contributor.authorLacerda A.T.
dc.date.accessioned2024-03-12T23:55:41Z
dc.date.available2024-03-12T23:55:41Z
dc.date.issued2019
dc.description.abstract© 2019, Associacao Brasileira de Psiquiatria. All rights reserved. Objective: In schizophrenia, scores reflecting deficits in different cognitive processes are strongly correlated, making it difficult to establish a solid relationship between different cognitive mechanisms and other features of this disorder. The objective of this study was to explore whether three frequently postulated executive functions (updating, shifting, and inhibition) could be compared between groups and considered independently in terms of their respective roles in functional outcome. Methods: This study relied on confirmatory factor analysis of schizophrenia patients (n=141) and healthy controls (n=119). The main analyses examined the degree to which three executive functions (updating, set-shifting, and inhibition) could be separated in schizophrenia and compared this model among groups. Structural equation modeling analysis was also performed to examine the extent to which executive function components contribute to functional outcome in schizophrenia. Results: Multiple-group confirmatory factor analysis with unconstrained model parameters indicated that the full three-factor model may fit the data in both groups (χ 2 = 61.48, degrees of freedom = 34, p < 0.001, comparative fit index = 0.95; standardized root mean square residual = 0.037; root mean square error of approximation = 0.04; Akaike’s information criteria = 169.49; normed fit index = 0.90), although there was also a good data fit for the patient group with a two-factor model. In the patient group, structural equation modeling suggested that shifting and (principally) updating were associated with the general measure of functional outcome (regression path coefficients: 0.34, p < 0.005; 0.39, p < 0.005, respectively), although when combined the mechanisms fail to contribute. Conclusion: This data suggests that the factor structure may be similar but not identical between groups, and both updating and shifting may play an important role in functional outcome in schizophrenia.
dc.description.firstpage22
dc.description.issuenumber1
dc.description.lastpage30
dc.description.volume41
dc.identifier.doi10.1590/1516-4446-2018-0021
dc.identifier.issn1516-4446
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/35406
dc.relation.ispartofRevista Brasileira de Psiquiatria
dc.rightsAcesso Aberto
dc.subject.otherlanguageExecutive functions
dc.subject.otherlanguageFunctional outcome
dc.subject.otherlanguageSchizophrenia
dc.titleComponent mechanisms of executive function in schizophrenia and their contribution to functional outcomes
dc.typeArtigo
local.scopus.citations12
local.scopus.eid2-s2.0-85061482808
local.scopus.subjectAdolescent
local.scopus.subjectAdult
local.scopus.subjectAged
local.scopus.subjectAged, 80 and over
local.scopus.subjectCase-Control Studies
local.scopus.subjectEducational Status
local.scopus.subjectExecutive Function
local.scopus.subjectFemale
local.scopus.subjectHumans
local.scopus.subjectInhibition (Psychology)
local.scopus.subjectMale
local.scopus.subjectMemory Disorders
local.scopus.subjectMiddle Aged
local.scopus.subjectNeuropsychological Tests
local.scopus.subjectSchizophrenia
local.scopus.subjectYoung Adult
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85061482808&origin=inward
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