Alterations in functional connectivity are associated with white matter lesions and information processing efficiency in multiple sclerosis

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dc.contributor.authorSoares J.M.
dc.contributor.authorConde R.
dc.contributor.authorMagalhaes R.
dc.contributor.authorMarques P.
dc.contributor.authorMagalhaes R.
dc.contributor.authorGomes L.
dc.contributor.authorGoncalves O.F.
dc.contributor.authorArantes M.
dc.contributor.authorSampaio A.
dc.date.accessioned2024-03-12T19:21:34Z
dc.date.available2024-03-12T19:21:34Z
dc.date.issued2021
dc.description.abstract© 2020, Springer Science+Business Media, LLC, part of Springer Nature.Functional connectivity (FC) is typically altered in individuals with Multiple Sclerosis (MS). However, in relapsing-remitting multiple sclerosis (RRMS) patients, the relationship between brain FC, tissue integrity and cognitive impairment is still unclear as contradictory findings have been documented. In this exploratory study we compared both the whole brain connectome and resting state networks (RSNs) FC of twenty-one RRMS and seventeen healthy controls (HCs), using combined network based statistics and independent component analyses. The total white matter (WM) lesion volume and information processing efficiency were also correlated with FC in the RRMS group. Both whole brain connectome and individual RSNs FC were diminished in patients with RRMS compared to HC. Additionally, the reduction in FC was found to be a function of the total WM lesion volume, with greatest impact in those harboring the largest lesion volume. Finally, a positive correlation between FC and information processing efficiency was observed in RRMS. This complimentary whole brain and RSNs FC approach can contribute to clarify literature inconsistencies regarding FC alterations and provide new insights on the white matter structural damage in explaining functional abnormalities in RRMS.
dc.description.firstpage375
dc.description.issuenumber1
dc.description.lastpage388
dc.description.volume15
dc.identifier.doi10.1007/s11682-020-00264-z
dc.identifier.issn1931-7565
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/34718
dc.relation.ispartofBrain Imaging and Behavior
dc.rightsAcesso Restrito
dc.subject.otherlanguageFunctional connectivity
dc.subject.otherlanguageInformation processing efficiency
dc.subject.otherlanguageMultiple sclerosis
dc.subject.otherlanguageResting State
dc.subject.otherlanguageWhite matter lesion
dc.titleAlterations in functional connectivity are associated with white matter lesions and information processing efficiency in multiple sclerosis
dc.typeArtigo
local.scopus.citations8
local.scopus.eid2-s2.0-85081403092
local.scopus.subjectBrain
local.scopus.subjectHumans
local.scopus.subjectMagnetic Resonance Imaging
local.scopus.subjectMultiple Sclerosis
local.scopus.subjectMultiple Sclerosis, Relapsing-Remitting
local.scopus.subjectWhite Matter
local.scopus.updated2024-10-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85081403092&origin=inward
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