Diminishing risk-taking behavior by modulating activity in the prefrontal cortex: A direct current stimulation study

Página do item simplificado
dc.contributor.authorFecteau S.
dc.contributor.authorKnoch D.
dc.contributor.authorFregni F.
dc.contributor.authorSultani N.
dc.contributor.authorBoggio P.
dc.contributor.authorPascual-Leone A.
dc.date.accessioned2024-03-13T01:39:20Z
dc.date.available2024-03-13T01:39:20Z
dc.date.issued2007
dc.description.abstractStudies have shown increased risk taking in healthy individuals after low-frequency repetitive transcranial magnetic stimulation, known to transiently suppress cortical excitability, over the right dorsolateral prefrontal cortex (DLPFC). It appears, therefore, plausible that differential modulation of DLPFC activity, increasing the right while decreasing the left, might lead to decreased risk taking, which could hold clinical relevance as excessively risky decision making is observed in clinical populations leading to deleterious consequences. The goal of the present study was to investigate whether risk-taking behaviors could be decreased using concurrent anodal transcranial direct current stimulation (tDCS) of the right DLPFC, which allows upregulation of brain activity, with cathodal tDCS of the left DLPCF, which downregulates activity. Thirty-six healthy volunteers performed the risk task while they received either anodal over the right with cathodal over the left DLPFC, anodal over the left with cathodal over the right DLPFC, or sham stimulation. We hypothesized that right anodal/left cathodal would decrease risk-taking behavior compared with left anodal/right cathodal or sham stimulation. As predicted, during right anodal/left cathodal stimulation over the DLPFC, participants chose more often the safe prospect compared with the other groups. Moreover, these participants appeared to be insensitive to the reward associated with the prospects. These findings support the notion that the interhemispheric balance of activity across the DLPFCs is critical in decision-making behaviors. Most importantly, the observed suppression of risky behaviors suggests that populations with boundless risk-taking behaviors leading to negative real-life consequences, such as individuals with addiction, might benefit from such neuromodulation-based approaches. Copyright © 2007 Society for Neuroscience.
dc.description.firstpage12500
dc.description.issuenumber46
dc.description.lastpage12505
dc.description.volume27
dc.identifier.doi10.1523/JNEUROSCI.3283-07.2007
dc.identifier.issn0270-6474
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/37619
dc.relation.ispartofJournal of Neuroscience
dc.rightsAcesso Aberto
dc.subject.otherlanguageDecision making
dc.subject.otherlanguageDorsolateral prefrontal cortex
dc.subject.otherlanguageInhibitory control
dc.subject.otherlanguageLaterality
dc.subject.otherlanguageRisk-taking behavior
dc.subject.otherlanguagetDCS
dc.titleDiminishing risk-taking behavior by modulating activity in the prefrontal cortex: A direct current stimulation study
dc.typeArtigo
local.scopus.citations374
local.scopus.eid2-s2.0-36248957109
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=36248957109&origin=inward
Arquivos
Coleções
Artigos de periódico