Implicações da disbiose no comportamento e cognição em crianças que possuem o TEA
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Tipo
TCC
Data de publicação
2024-12
Periódico
Citações (Scopus)
Autores
Freire, Marianna Pesck de Alvarenga
Orientador
Fiorino, Patricia
Título da Revista
ISSN da Revista
Título de Volume
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Resumo
Essa revisão constituiu em investigar as implicações da disbiose intestinal no
comportamento e cognição de crianças com TEA , destacando a interação entre a
microbiota intestinal e o eixo intestino-cérebro. Foi realizada uma revisão bibliográfica
para comparar as diferenças entre a microbiota intestinal de crianças com TEA e
crianças neuroatípicas, analisar os fatores nutricionais que influenciam essa
microbiota e examinar a relação entre as alterações na microbiota intestinal e os
sintomas comportamentais e cognitivos, onde se utilizou 49 artigos, 43 em inglês e 6
em português e 13 sites, focando nos que apresentavam estudos relacionados com
as palavras chaves utilizadas. Os resultados revelaram que crianças com TEA
apresentam desequilíbrios acentuados na microbiota intestinal, frequentemente
associados a manifestações gastrointestinais, comportamentais e cognitivas,
mediadas por vias neuroimunes, neuroendócrinas e metabólicas. O uso de estratégias
nutricionais, uso de prebióticos e probióticos, e terapias emergentes, como o
transplante de microbiota fecal, tem mostrado potencial na modulação da microbiota
e na redução de sintomas. Contudo, ainda há lacunas na literatura, como a ausência
de estudos correlacionais e a ausência de metodologias padronizadas e amostras
representativas. O estudo conclui que a microbiota intestinal desempenha um papel
central no entendimento e manejo clínico do TEA, reforçando a necessidade de
pesquisas futuras que aprofundem os mecanismos causais e explorem intervenções
baseadas na modulação da microbiota.
This study investigates the implications of intestinal dysbiosis on behavior and cognition in children with Autism Spectrum Disorder (ASD), emphasizing the interaction between the gut microbiota and the gut-brain axis. A literature review was conducted to compare the differences in gut microbiota between children with ASD and neurotypical children, analyze the nutritional factors influencing this microbiota, and examine the relationship between changes in gut microbiota and behavioral and cognitive symptoms. The review included 49 articles, 43 in English and 6 in Portuguese, and 13 websites, focusing on those related to the keywords used. The results revealed that children with ASD exhibit significant imbalances in their gut microbiota, often associated with gastrointestinal, behavioral, and cognitive manifestations, mediated by neuroimmune, neuroendocrine, and metabolic pathways. The use of nutritional strategies, prebiotics, probiotics, and emerging therapies such as fecal microbiota transplantation (FMT) has shown potential in modulating the microbiota and reducing symptoms. However, there are still gaps in the literature, such as the lack of correlational studies, standardized methodologies, and representative samples. The study concludes that gut microbiota plays a central role in understanding and clinically managing ASD, highlighting the need for future research to deepen causal mechanisms and explore microbiota-based interventions.
This study investigates the implications of intestinal dysbiosis on behavior and cognition in children with Autism Spectrum Disorder (ASD), emphasizing the interaction between the gut microbiota and the gut-brain axis. A literature review was conducted to compare the differences in gut microbiota between children with ASD and neurotypical children, analyze the nutritional factors influencing this microbiota, and examine the relationship between changes in gut microbiota and behavioral and cognitive symptoms. The review included 49 articles, 43 in English and 6 in Portuguese, and 13 websites, focusing on those related to the keywords used. The results revealed that children with ASD exhibit significant imbalances in their gut microbiota, often associated with gastrointestinal, behavioral, and cognitive manifestations, mediated by neuroimmune, neuroendocrine, and metabolic pathways. The use of nutritional strategies, prebiotics, probiotics, and emerging therapies such as fecal microbiota transplantation (FMT) has shown potential in modulating the microbiota and reducing symptoms. However, there are still gaps in the literature, such as the lack of correlational studies, standardized methodologies, and representative samples. The study concludes that gut microbiota plays a central role in understanding and clinically managing ASD, highlighting the need for future research to deepen causal mechanisms and explore microbiota-based interventions.
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Palavras-chave
TEA , disbiose intestinal , microbiota intestinal , comportamento , cognição , ASD , intestinal dysbiosis , gut microbiota , behavior , cognition