Transcranial direct current stimulation based metaplasticity protocols in working memory

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dc.contributor.authorCarvalho S.
dc.contributor.authorBoggio P.S.
dc.contributor.authorGoncalves O.F.
dc.contributor.authorVigario A.R.
dc.contributor.authorFaria M.
dc.contributor.authorSilva S.
dc.contributor.authorGaudencio Do Rego G.
dc.contributor.authorFregni F.
dc.contributor.authorLeite J.
dc.date.accessioned2024-03-13T00:57:43Z
dc.date.available2024-03-13T00:57:43Z
dc.date.issued2015
dc.description.abstract© 2015 Elsevier Inc. All rights reserved.Background: It has been already shown that delivering tDCS that are spaced by an interval alters its impact on motor plasticity. These effects can be explained, based on metaplasticity in which a previous modification of activity in a neuronal network can change the effects of subsequent interventions in the same network. But to date there is limited data assessing metaplasticity effects in cognitive functioning. Objectives: The aim of this study was to test several tDCS-based metaplasticity protocols in working memory (WM), by studying the impact of various interstimulation intervals in the performance of a 3-back task. Methods: Fifteen healthy volunteers per experiment participated in this study. Experiments 1 and 2 tested an anodal tDCS-induced metaplasticity protocol (1 mA, 10 + 10′) with 3 interstimulation intervals (10, 30, and 60 min). Experiment 3 determined the effects of a similar protocol - with a 10-min interval between two sessions of cathodal tDCS or anodal plus cathodal tDCS (1 mA, 10 + 10′). Results: Two consecutive sessions of anodal tDCS delivered with a 10 min interval between them did not improve WM performance (P =.095). This effect remained the same if the interval was increased to 30 or 60 min. In contrast, when a 10 min interval was given between two consecutive cathodal tDCS sessions, performance in the 3 back task increased (P =.042). Conclusions: These results suggest that the polarity effects of tDCS on working memory are dependent on the previous level of activity of the recruited neural population.
dc.description.firstpage289
dc.description.issuenumber2
dc.description.lastpage294
dc.description.volume8
dc.identifier.doi10.1016/j.brs.2014.11.011
dc.identifier.issn1876-4754
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/36227
dc.relation.ispartofBrain Stimulation
dc.rightsAcesso Restrito
dc.subject.otherlanguageDLPFC
dc.subject.otherlanguageMetaplasticity
dc.subject.otherlanguageN-Back
dc.subject.otherlanguagePre-conditioning and conditioning tDCS
dc.subject.otherlanguageWorking memory
dc.titleTranscranial direct current stimulation based metaplasticity protocols in working memory
dc.typeArtigo
local.scopus.citations37
local.scopus.eid2-s2.0-84922949646
local.scopus.subjectCognition
local.scopus.subjectFemale
local.scopus.subjectHumans
local.scopus.subjectMale
local.scopus.subjectMemory, Short-Term
local.scopus.subjectNeuronal Plasticity
local.scopus.subjectPrefrontal Cortex
local.scopus.subjectTime Factors
local.scopus.subjectTranscranial Direct Current Stimulation
local.scopus.subjectYoung Adult
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84922949646&origin=inward
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