Brain Fog in Hypothyroidism: Understanding the Patient's Perspective

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dc.contributor.authorEttleson M.D.
dc.contributor.authorRaine A.
dc.contributor.authorBatistuzzo A.
dc.contributor.authorBatista S.P.
dc.contributor.authorMcAninch E.
dc.contributor.authorTeixeira M.C.T.V.
dc.contributor.authorJonklaas J.
dc.contributor.authorLaiteerapong N.
dc.contributor.authorRibeiro M.O.
dc.contributor.authorBianco A.C.
dc.date.accessioned2024-03-12T19:15:29Z
dc.date.available2024-03-12T19:15:29Z
dc.date.issued2022
dc.description.abstract© 2021 AACEObjective: Patient-centered studies have shown that several patients on thyroid hormone replacement therapy for hypothyroidism exhibit persistent symptoms, including “brain fog.” Here, we aimed to determine which of these specific symptoms are associated with brain fog, identify patient-reported factors that modify these symptoms, and identify patient concerns related to brain fog not included in thyroid-specific questionnaires. Methods: A survey on brain fog symptoms adapted from thyroid-specific patient-reported outcome was distributed online. Textual data analysis was performed to identify common areas of concern from open-ended survey responses. Results: A total of 5170 participants reporting brain fog while being treated for hypothyroidism were included in the analysis. Of these, 2409 (46.6%) participants reported symptom onset prior to the diagnosis of hypothyroidism, and 4096 (79.2%) participants experienced brain fog symptoms frequently. Of the symptoms listed, participants associated fatigue and forgetfulness most frequently with brain fog. More rest was the most common factor provided for improving symptoms. The textual data analysis identified areas of concern that are not often included in thyroid-specific quality of life questionnaires, including a focus on the diagnosis of hypothyroidism, the types and doses of medications, and the patient-doctor relationship. Conclusion: Brain fog in patients treated for hypothyroidism was associated most frequently with fatigue and cognitive symptoms. Several additional areas of patient concern were found to be associated with brain fog, which are not typically addressed in thyroid-specific questionnaires.
dc.description.firstpage257
dc.description.issuenumber3
dc.description.lastpage264
dc.description.volume28
dc.identifier.doi10.1016/j.eprac.2021.12.003
dc.identifier.issn1934-2403
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/34390
dc.relation.ispartofEndocrine Practice
dc.rightsAcesso Restrito
dc.subject.otherlanguagebrain fog
dc.subject.otherlanguagefatigue
dc.subject.otherlanguagehypothyroidism
dc.subject.otherlanguagememory
dc.titleBrain Fog in Hypothyroidism: Understanding the Patient's Perspective
dc.typeArtigo
local.scopus.citations23
local.scopus.eid2-s2.0-85121836703
local.scopus.subjectBrain
local.scopus.subjectHormone Replacement Therapy
local.scopus.subjectHumans
local.scopus.subjectHypothyroidism
local.scopus.subjectQuality of Life
local.scopus.subjectSurveys and Questionnaires
local.scopus.subjectThyroxine
local.scopus.updated2024-12-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85121836703&origin=inward
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